|
|
EFHC2 |
EF-hand domain containing 2 |
|
|
|
|
|
EGR1 |
early growth response 1 |
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- NGF-stimulated transcription
- NGF-stimulated transcription
- Interferon alpha/beta signaling
|
|
|
|
|
EXOC2 |
exocyst complex component 2 |
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Insulin processing
- VxPx cargo-targeting to cilium
|
|
|
|
|
FRAT2 |
FRAT regulator of WNT signaling pathway 2 |
- Beta-catenin phosphorylation cascade
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
|
|
|
|
|
FZR1 |
fizzy and cell division cycle 20 related 1 |
- Autodegradation of Cdh1 by Cdh1:APC/C
- SCF-beta-TrCP mediated degradation of Emi1
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
- Regulation of APC/C activators between G1/S and early anaphase
- Phosphorylation of Emi1
- Senescence-Associated Secretory Phenotype (SASP)
- CDK-mediated phosphorylation and removal of Cdc6
- Cyclin A:Cdk2-associated events at S phase entry
- Transcriptional Regulation by VENTX
- Aberrant regulation of mitotic exit in cancer due to RB1 defects
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
|
|
|
GALNT12 |
polypeptide N-acetylgalactosaminyltransferase 12 |
- Defective GALNT12 causes colorectal cancer 1 (CRCS1)
- O-linked glycosylation of mucins
|
|
|
|
|
GGA1 |
golgi associated, gamma adaptin ear containing, ARF binding protein 1 |
- TBC/RABGAPs
- Amyloid fiber formation
|
|
|
|
|
GGA3 |
golgi associated, gamma adaptin ear containing, ARF binding protein 3 |
- TBC/RABGAPs
- MET receptor recycling
- Amyloid fiber formation
|
|
|
|
|
GLIS1 |
GLIS family zinc finger 1 |
|
|
|
|
|
GLIS2 |
GLIS family zinc finger 2 |
|
|
- Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
|
|
|
GMNN |
geminin DNA replication inhibitor |
- CDT1 association with the CDC6:ORC:origin complex
- Activation of the pre-replicative complex
|
|
|
|
|
H2BU1 |
H2B.U histone 1 |
- Recognition and association of DNA glycosylase with site containing an affected pyrimidine
- Cleavage of the damaged pyrimidine
- Recognition and association of DNA glycosylase with site containing an affected purine
- Recognition and association of DNA glycosylase with site containing an affected purine
- Cleavage of the damaged purine
- Cleavage of the damaged purine
- Meiotic synapsis
- Packaging Of Telomere Ends
- Pre-NOTCH Transcription and Translation
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- PRC2 methylates histones and DNA
- Condensation of Prophase Chromosomes
- Oxidative Stress Induced Senescence
- Senescence-Associated Secretory Phenotype (SASP)
- DNA Damage/Telomere Stress Induced Senescence
- HDACs deacetylate histones
- HATs acetylate histones
- HATs acetylate histones
- SIRT1 negatively regulates rRNA expression
- ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
- NoRC negatively regulates rRNA expression
- NoRC negatively regulates rRNA expression
- B-WICH complex positively regulates rRNA expression
- DNA methylation
- Transcriptional regulation by small RNAs
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Ub-specific processing proteases
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- Deposition of new CENPA-containing nucleosomes at the centromere
- G2/M DNA damage checkpoint
- RNA Polymerase I Promoter Opening
- RNA Polymerase I Promoter Escape
- RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Estrogen-dependent gene expression
- Meiotic recombination
- HCMV Early Events
- HCMV Late Events
- Transcriptional regulation of granulopoiesis
- Inhibition of DNA recombination at telomere
- Amyloid fiber formation
|
|
|
|
|
HLA-DOB |
major histocompatibility complex, class II, DO beta |
- MHC class II antigen presentation
|
|
|
|
|
HNRNPC |
heterogeneous nuclear ribonucleoprotein C |
- SUMOylation of RNA binding proteins
- mRNA Splicing - Major Pathway
- Processing of Capped Intron-Containing Pre-mRNA
|
|
|
|
|
HNRNPU |
heterogeneous nuclear ribonucleoprotein U |
- mRNA Splicing - Major Pathway
- Processing of Capped Intron-Containing Pre-mRNA
|
|
|
|
|
HUWE1 |
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 |
- Neutrophil degranulation
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
- Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
|
|
|
ISOC2 |
isochorismatase domain containing 2 |
|
|
|
|
|
LATS2 |
large tumor suppressor kinase 2 |
|
|
|
|
|
MAF1 |
MAF1 homolog, negative regulator of RNA polymerase III |
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
|
|
|
|
|
MAP3K5 |
mitogen-activated protein kinase kinase kinase 5 |
- Oxidative Stress Induced Senescence
- Oxidative Stress Induced Senescence
|
|
|