TRIM14 and ADAMTS12

Data Source:
BioGRID (two hybrid)

		TRIM14	ADAMTS12
Description		tripartite motif containing 14	ADAM metallopeptidase with thrombospondin type 1 motif 12
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Cytosol Phagocytic Vesicle	Extracellular Matrix
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	Metalloendopeptidase Activity Protein Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity	Cell-matrix Adhesion Cell Migration Proteoglycan Catabolic Process Extracellular Matrix Organization Negative Regulation Of Chondrocyte Differentiation Regulation Of Inflammatory Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To BMP Stimulus Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Cellular Response To Hepatocyte Growth Factor Stimulus
Pathways		Interferon gamma signaling	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Multiple sclerosis ( 31604244)	Blond vs. brown/black hair color ( 30531825) Height ( 31217584) Metabolite levels ( 23823483) Mortality in heart failure ( 20400778) Neurofibrillary tangles ( 31497858) Seasonality and depression ( 30217971) Stroke (pediatric) ( 22990015)
Interacting Genes		84 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652	7 interacting genes: CALM2 COIL IHO1 MEOX2 MYL6 TP53BP2 TRIM14
Entrez ID		9830	81792
HPRD ID		05948	05862
Ensembl ID		ENSG00000106785	ENSG00000151388
Uniprot IDs		A0A024R165 Q14142	D6REX0 P58397
PDB IDs		6JBM
Enriched GO Terms of Interacting Partners?
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