TRIM14 and ZFP36L2

Data Source:
BioGRID (two hybrid)

		TRIM14	ZFP36L2
Description		tripartite motif containing 14	ZFP36 ring finger protein like 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Cytosol Phagocytic Vesicle	Nucleus Cytoplasm
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	RNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Catabolic Process Response To Wounding Hemopoiesis T Cell Differentiation In Thymus Somatic Stem Cell Population Maintenance Regulation Of MRNA Stability Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of B Cell Differentiation Negative Regulation Of Fat Cell Differentiation Somatic Stem Cell Division Definitive Hemopoiesis 3'-UTR-mediated MRNA Destabilization ERK1 And ERK2 Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Stem Cell Differentiation
Pathways		Interferon gamma signaling
Drugs
Diseases
GWAS		Multiple sclerosis ( 31604244)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diastolic blood pressure ( 27841878 31469255) Estimated glomerular filtration rate ( 31152163) Glucose homeostasis traits ( 25524916) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Offspring birth weight ( 31043758) Platelet count ( 27863252) Polycystic ovary syndrome ( 21151128) Red blood cell count ( 29403010 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 28739976)
Interacting Genes		84 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652	1 interacting genes: TRIM14
Entrez ID		9830	678
HPRD ID		05948	18319
Ensembl ID		ENSG00000106785	ENSG00000152518
Uniprot IDs		A0A024R165 Q14142	P47974
PDB IDs		6JBM	1RGO
Enriched GO Terms of Interacting Partners?
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