SERTAD2 and PLA2G6

Data Source:
BioGRID (two hybrid)

		SERTAD2	PLA2G6
Description		SERTA domain containing 2	phospholipase A2 group VI
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Extracellular Space Mitochondrion Cytosol Plasma Membrane Integral Component Of Membrane Pseudopodium Centriolar Satellite
	Molecular Function	Transcription Coactivator Activity Protein Binding Transcription Regulator Activity	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Lysophospholipase Activity Phospholipase A2 Activity Protein Binding Calmodulin Binding Palmitoyl-CoA Hydrolase Activity Hydrolase Activity Identical Protein Binding Calcium-independent Phospholipase A2 Activity Phosphatidyl Phospholipase B Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine) Myristoyl-CoA Hydrolase Activity
	Biological Process	Negative Regulation Of Cell Growth Chromatin-mediated Maintenance Of Transcription	Chemotaxis Antibacterial Humoral Response Cardiolipin Biosynthetic Process Phosphatidylcholine Catabolic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cardiolipin Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Phosphatidylethanolamine Catabolic Process Platelet Activating Factor Metabolic Process Phosphatidic Acid Metabolic Process
Pathways			Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PE Role of phospholipids in phagocytosis COPI-independent Golgi-to-ER retrograde traffic
Drugs			Quinacrine
Diseases			Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Neuroferritinopathy; Aceruloplasminemia Parkinson's disease (PD)
GWAS		Antisaccade task score ( 31596458) Apolipoprotein B levels ( 32203549) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) TPE interval (resting) ( 32386560) Visceral fat ( 22589738)	Apolipoprotein A1 levels ( 32203549) Body fat percentage ( 26833246) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cutaneous nevi ( 21478494 19578365) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) Mammographic density (dense area) ( 25342443) Melanoma ( 21983787 28212542) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 32341527 30429480) Percent mammographic density ( 25342443) Platelet distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Triglyceride levels ( 32203549 28334899 32154731) Triglycerides ( 24097068 20686565)
Interacting Genes		25 interacting genes: ATG12 C1orf109 CDC7 CKS1B CREBBP CTNNA3 E2F1 ESPNL HELLS IGFN1 KAT2B KAT5 PARVG PIK3R3 PLA2G6 PRKAB2 STRA8 SUPT7L TFDP1 TNS2 TRIM28 XPO1 ZNF524 ZNF581 ZSCAN22	11 interacting genes: CALM1 CCDC33 CEP76 MAT2B NUP93 RCBTB2 RUSC1 SERTAD2 TRIM50 USP54 ZBTB42
Entrez ID		9792	8398
HPRD ID		18040	04675
Ensembl ID		ENSG00000179833	ENSG00000184381
Uniprot IDs		Q14140	O60733
PDB IDs
Enriched GO Terms of Interacting Partners?
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