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PLA2G6
Description
phospholipase A2 group VI
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Mitochondrion
Cytosol
Plasma Membrane
Integral Component Of Membrane
Pseudopodium
Centriolar Satellite
Molecular Function
1-alkyl-2-acetylglycerophosphocholine Esterase Activity
Lysophospholipase Activity
Phospholipase A2 Activity
Protein Binding
Calmodulin Binding
Palmitoyl-CoA Hydrolase Activity
Hydrolase Activity
Identical Protein Binding
Calcium-independent Phospholipase A2 Activity
Phosphatidyl Phospholipase B Activity
Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine)
Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
Myristoyl-CoA Hydrolase Activity
Biological Process
Chemotaxis
Antibacterial Humoral Response
Cardiolipin Biosynthetic Process
Phosphatidylcholine Catabolic Process
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Cardiolipin Acyl-chain Remodeling
Phosphatidylcholine Acyl-chain Remodeling
Phosphatidylethanolamine Acyl-chain Remodeling
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Phosphatidylethanolamine Catabolic Process
Platelet Activating Factor Metabolic Process
Phosphatidic Acid Metabolic Process
Pathways
Acyl chain remodelling of PC
Acyl chain remodeling of CL
Acyl chain remodelling of PE
Role of phospholipids in phagocytosis
COPI-independent Golgi-to-ER retrograde traffic
Drugs
Quinacrine
Diseases
Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Neuroferritinopathy; Aceruloplasminemia
Parkinson's disease (PD)
GWAS
Apolipoprotein A1 levels (
32203549
)
Body fat percentage (
26833246
)
Brain morphology (MOSTest) (
32665545
)
Breast cancer (
29059683
)
C-reactive protein levels or triglyceride levels (pleiotropy) (
27286809
)
Cutaneous nevi (
21478494
19578365
)
HDL cholesterol levels (
32203549
)
High light scatter reticulocyte count (
32888494
)
Mammographic density (dense area) (
25342443
)
Melanoma (
21983787
28212542
)
Nevus count (
30429480
)
Nevus count or cutaneous melanoma (
32341527
30429480
)
Percent mammographic density (
25342443
)
Platelet distribution width (
32888494
)
Refractive error (
32231278
)
Reticulocyte count (
32888494
)
Triglyceride levels (
32203549
28334899
32154731
)
Triglycerides (
24097068
20686565
)
Novel Interacting Genes
1 novel interacting genes:
CACNA1I
Interacting Genes
11 interacting genes:
CALM1
CCDC33
CEP76
MAT2B
NUP93
RCBTB2
RUSC1
SERTAD2
TRIM50
USP54
ZBTB42
Entrez ID
8398
HPRD ID
04675
Ensembl ID
ENSG00000184381
Uniprot IDs
O60733
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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