ARHGAP32 and NPHP1

Data Source:
BioGRID (two hybrid)

		ARHGAP32	NPHP1
Description		Rho GTPase activating protein 32	nephrocystin 1
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GO Annotations	Cellular Component	Golgi Membrane Fibrillar Center Nucleoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Cell Cortex Endosome Membrane Postsynaptic Density Actin Cytoskeleton Dendritic Spine	Cytoplasm Cytosol Cytoskeleton Cell-cell Junction Adherens Junction Bicellular Tight Junction Cilium Membrane Motile Cilium Photoreceptor Connecting Cilium
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol Phosphate Binding	Structural Molecule Activity Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Signal Transduction Excretion Visual Behavior Cell Projection Organization Actin Cytoskeleton Organization Spermatid Differentiation Retina Development In Camera-type Eye Protein Localization Involved In Establishment Of Planar Polarity Ciliary Basal Body-plasma Membrane Docking Cell-cell Adhesion Positive Regulation Of Bicellular Tight Junction Assembly
Pathways		Rho GTPase cycle	Anchoring of the basal body to the plasma membrane
Drugs
Diseases			Joubert syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Senior-Loken syndrome
GWAS		Intracranial aneurysm ( 30823506) Iris color (L* coordinate) ( 29109912) Macular thickness ( 30535121) Metabolite levels (5-HIAA) ( 23319000) Refractive error ( 32231278)
Interacting Genes		33 interacting genes: ABI2 ATXN1 BCAR1 CAMK2N2 CDC42 CDH1 CDH2 CRK CRKL CTNNB1 DLG4 DZIP3 FYN GAB1 GAB2 GRAP GRB2 GRIN2A GRIN2B LHX2 MDFI MEGF10 NCK1 NCK2 NPHP1 NTRK1 PIK3R1 PLCG1 RAC1 RHOA SHC3 SRC TLE5	16 interacting genes: ADAM15 ARHGAP32 BCAR1 FBXO7 FLNA FLNB FLNC INVS KHDRBS1 NPHP3 NPHP4 PAK2 PTK2B TNK2 TUBB UBQLN4
Entrez ID		9743	4867
HPRD ID		12257	09524
Ensembl ID		ENSG00000134909	ENSG00000144061
Uniprot IDs		A7KAX9 Q86T64	C9JNM7 O15259
PDB IDs		3IUG	1S1N 6O1Q
Enriched GO Terms of Interacting Partners?
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