CCP110 and DCAF1

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CCP110	DCAF1
Description		centriolar coiled-coil protein 110	DDB1 and CUL4 associated factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Centriole Cytosol Cilium Protein-containing Complex	Fibrillar Center Nucleus Nucleoplasm Cytoplasm COP9 Signalosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Protein Binding ATP Binding Estrogen Receptor Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity Histone Kinase Activity (H2A-T120 Specific)
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Ciliary Basal Body Organization Regulation Of Cytokinesis Positive Regulation Of Cilium Assembly Centrosome Duplication Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of Cilium Assembly Negative Regulation Of Centriole Elongation	Negative Regulation Of Transcription By RNA Polymerase II Viral Process Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Histone H2A-T120 Phosphorylation
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Ub-specific processing proteases AURKA Activation by TPX2	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Asthma ( 32296059)
Interacting Genes		13 interacting genes: AKAP9 CALM1 CALM3 CDK1 CDK2 CEP97 CETN1 CETN2 DCAF1 PCNT PNMA1 TFIP11 USP33	19 interacting genes: ATM ATR CCP110 EXO1 FOXM1 H3-3A H3-4 H3C1 HLTF KATNA1 NF2 PRKDC PYGO2 RAG1 RBX1 SAMHD1 TET2 TP53 UBE2D2
Entrez ID		9738	9730
HPRD ID		10848	11674
Ensembl ID		ENSG00000103540	ENSG00000145041
Uniprot IDs		O43303	Q9Y4B6
PDB IDs			3WA0 4CC9 4P7I 4PXW 4Z8L 5AJA 5JK7 6N45
Enriched GO Terms of Interacting Partners?
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