DCAF1 and KATNA1

Data Source:
BioGRID (affinity chromatography technology, pull down, enzymatic study)

		DCAF1	KATNA1
Description		DDB1 and CUL4 associated factor 1	katanin catalytic subunit A1
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm COP9 Signalosome Cul4-RING E3 Ubiquitin Ligase Complex	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Microtubule Microtubule Cytoskeleton Midbody Mitotic Spindle Pole
	Molecular Function	Protein Binding ATP Binding Estrogen Receptor Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity Histone Kinase Activity (H2A-T120 Specific)	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Isomerase Activity ATPase Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Viral Process Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Histone H2A-T120 Phosphorylation	Cell Cycle Cytoplasmic Microtubule Organization Microtubule Severing Cell Division
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 32296059)	Brain morphology (MOSTest) ( 32665545) Lung cancer ( 27393504) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)
Interacting Genes		19 interacting genes: ATM ATR CCP110 EXO1 FOXM1 H3-3A H3-4 H3C1 HLTF KATNA1 NF2 PRKDC PYGO2 RAG1 RBX1 SAMHD1 TET2 TP53 UBE2D2	9 interacting genes: APP CLK1 CLU DCAF1 DYNC1H1 DYRK2 KATNB1 LIPE PAFAH1B1
Entrez ID		9730	11104
HPRD ID		11674	05986
Ensembl ID		ENSG00000145041	ENSG00000186625
Uniprot IDs		Q9Y4B6	A8K7S5 O75449
PDB IDs		3WA0 4CC9 4P7I 4PXW 4Z8L 5AJA 5JK7 6N45	5ZQL 5ZQM
Enriched GO Terms of Interacting Partners?
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