DCAF1 and SAMHD1

Data Source:
BioGRID (enzymatic study, x-ray crystallography, pull down, affinity chromatography technology)

		DCAF1	SAMHD1
Description		DDB1 and CUL4 associated factor 1	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm COP9 Signalosome Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Nucleoplasm Plasma Membrane Site Of Double-strand Break Tetraspanin-enriched Microdomain
	Molecular Function	Protein Binding ATP Binding Estrogen Receptor Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity Histone Kinase Activity (H2A-T120 Specific)	Nucleic Acid Binding Single-stranded DNA Binding RNA Binding Ribonuclease Activity Protein Binding GTP Binding Zinc Ion Binding DGTPase Activity Triphosphoric Monoester Hydrolase Activity DGTP Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Viral Process Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Histone H2A-T120 Phosphorylation	Double-strand Break Repair Via Homologous Recombination DGTP Catabolic Process Immune Response Cellular Response To DNA Damage Stimulus Deoxyribonucleotide Catabolic Process Viral Process Somatic Hypermutation Of Immunoglobulin Genes Regulation Of Innate Immune Response DATP Catabolic Process Protein Homotetramerization Defense Response To Virus Type I Interferon Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway RNA Phosphodiester Bond Hydrolysis DNA Strand Resection Involved In Replication Fork Processing
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Nucleobase catabolism Interferon alpha/beta signaling
Drugs
Diseases			Aicardi-Goutieres Syndrome (AGS)
GWAS		Asthma ( 32296059)	Height ( 28552196)
Interacting Genes		19 interacting genes: ATM ATR CCP110 EXO1 FOXM1 H3-3A H3-4 H3C1 HLTF KATNA1 NF2 PRKDC PYGO2 RAG1 RBX1 SAMHD1 TET2 TP53 UBE2D2	11 interacting genes: ACTB APP ARAP3 DCAF1 DYSF FAM13B FBXO25 FBXO7 SUMO2 TIRAP TRIM21
Entrez ID		9730	25939
HPRD ID		11674	08418
Ensembl ID		ENSG00000145041	ENSG00000101347
Uniprot IDs		Q9Y4B6	Q59H15 Q9Y3Z3
PDB IDs		3WA0 4CC9 4P7I 4PXW 4Z8L 5AJA 5JK7 6N45	2E8O 3U1N 4BZB 4BZC 4CC9 4MZ7 4Q7H 4QFX 4QFY 4QFZ 4QG0 4QG1 4QG2 4QG4 4RXO 4RXP 4RXQ 4RXR 4RXS 4TNP 4TNQ 4TNR 4TNX 4TNY 4TNZ 4TO0 4TO1 4TO2 4TO3 4TO4 4TO5 4TO6 4ZWE 4ZWG 5AO0 5AO1 5AO2 5AO3 5AO4 6CM2 6DW3 6DW4 6DW5 6DW7 6DWD 6DWJ 6DWK 6TX0 6TXA 6TXC 6TXE 6TXF 6U6X 6U6Y 6U6Z 6XU1 6YOM
Enriched GO Terms of Interacting Partners?
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