CD72 and BLNK

Data Source:
HPRD (in vivo)

		CD72	BLNK
Description		CD72 molecule	B cell linker
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Carbohydrate Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Enzyme Binding Signaling Adaptor Activity SH2 Domain Binding Protein Tyrosine Kinase Binding
	Biological Process	Cell Adhesion	Inflammatory Response Humoral Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Gene Expression B Cell Differentiation Intracellular Signal Transduction B Cell Receptor Signaling Pathway
Pathways		Other semaphorin interactions	Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases			Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Blood protein levels ( 30072576) Electroencephalogram traits ( 25387704)	Mean spheric corpuscular volume ( 32888494)
Interacting Genes		22 interacting genes: ATP6AP2 BIK BLNK CD5 CGRRF1 CLDN7 CREB3L1 GPR152 GRAMD1C GRB2 LHFPL5 LMNA LRRC25 LSMEM2 LYN MS4A3 MS4A7 NRG1 PTPN6 SEMA4D SPACA1 SYK	25 interacting genes: AR BTK CBL CBLB CD72 CD79A CMTM3 CRKL EGFR ERBB2 ERBB3 GAB1 GRAP2 GRB2 ITK KIT LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1
Entrez ID		971	29760
HPRD ID		00118	05153
Ensembl ID		ENSG00000137101	ENSG00000095585
Uniprot IDs		P21854 Q5TLG3	Q2MD54 Q2MD59 Q8WV28
PDB IDs
Enriched GO Terms of Interacting Partners?
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