BLNK and MAP4K1

Data Source:
HPRD (in vitro)

		BLNK	MAP4K1
Description		B cell linker	mitogen-activated protein kinase kinase kinase kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Ribonucleoprotein Granule	Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Enzyme Binding Signaling Adaptor Activity SH2 Domain Binding Protein Tyrosine Kinase Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Inflammatory Response Humoral Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Gene Expression B Cell Differentiation Intracellular Signal Transduction B Cell Receptor Signaling Pathway	Activation Of MAPKKK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Cell Population Proliferation Peptidyl-serine Phosphorylation Protein Autophosphorylation Cellular Response To Phorbol 13-acetate 12-myristate
Pathways		Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Fostamatinib
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Mean spheric corpuscular volume ( 32888494)	Diisocyanate-induced asthma ( 25918132)
Interacting Genes		25 interacting genes: AR BTK CBL CBLB CD72 CD79A CMTM3 CRKL EGFR ERBB2 ERBB3 GAB1 GRAP2 GRB2 ITK KIT LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1	22 interacting genes: ABL1 BLNK CARD11 CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 H2AC4 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 SHC1 SYK TMEM101
Entrez ID		29760	11184
HPRD ID		05153	03583
Ensembl ID		ENSG00000095585	ENSG00000104814
Uniprot IDs		Q2MD54 Q2MD59 Q8WV28	Q92918
PDB IDs			6CQD 6CQE 6CQF 6NFY 6NFZ 6NG0
Enriched GO Terms of Interacting Partners?
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