BLNK and CMTM3

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		BLNK	CMTM3
Description		B cell linker	CKLF like MARVEL transmembrane domain containing 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Ribonucleoprotein Granule	Extracellular Space Cytosol Integral Component Of Membrane Cytoplasmic Vesicle
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Enzyme Binding Signaling Adaptor Activity SH2 Domain Binding Protein Tyrosine Kinase Binding	Cytokine Activity Protein Binding
	Biological Process	Inflammatory Response Humoral Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Gene Expression B Cell Differentiation Intracellular Signal Transduction B Cell Receptor Signaling Pathway	Chemotaxis Signal Transduction
Pathways		Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Mean spheric corpuscular volume ( 32888494)
Interacting Genes		25 interacting genes: AR BTK CBL CBLB CD72 CD79A CMTM3 CRKL EGFR ERBB2 ERBB3 GAB1 GRAP2 GRB2 ITK KIT LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1	30 interacting genes: APOA5 APP AQP6 ARL13B BLNK BTK CREB3L1 ELOVL4 GJB1 GPR35 HSD17B11 IKBIP IL10RA LEUTX LMNA LRRC59 MAPK1 MEST MFSD14B MOB1A MOB3C MRM1 RABAC1 REEP4 RETREG3 SLC10A1 SPP1 STMN4 SYT2 VEZT
Entrez ID		29760	123920
HPRD ID		05153	16259
Ensembl ID		ENSG00000095585	ENSG00000140931
Uniprot IDs		Q2MD54 Q2MD59 Q8WV28	A0A024R6Y8 H3BUD5 Q96MX0
PDB IDs
Enriched GO Terms of Interacting Partners?
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