FEZ2 and RAB3GAP1

Data Source:
BioGRID (two hybrid)

		FEZ2	RAB3GAP1
Description		fasciculation and elongation protein zeta 2	RAB3 GTPase activating protein catalytic subunit 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Axon	Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Protein-containing Complex Extracellular Exosome Endoplasmic Reticulum Tubular Network Postsynapse
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Signal Transduction Nervous System Development Axon Guidance Negative Regulation Of Autophagosome Assembly	Brain Development Hypothalamus Development Lipid Droplet Organization Camera-type Eye Development Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Short-term Neuronal Synaptic Plasticity Excitatory Postsynaptic Potential Face Morphogenesis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Autophagosome Assembly
Pathways			COPI-independent Golgi-to-ER retrograde traffic RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Warburg micro syndrome Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		Apolipoprotein A1 levels ( 32203549) Intraocular pressure ( 29617998) Metabolite levels ( 23823483) Offspring birth weight ( 31043758)	Blood metabolite levels ( 24816252) Body mass index ( 25673413) Cholesterol, total ( 24097068 25961943 20686565) Corneal structure ( 21979947) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Sudden cardiac arrest in coronary artery disease ( 23593153)
Interacting Genes		18 interacting genes: BRD1 CLASP2 DRAP1 FEZ1 KPNA2 NEK1 PDCD7 PRKCZ RAB3GAP1 RAI14 SAP30L SCOC SMC3 TBC1D25 TEDC2 TLK2 WWC1 ZNF251	8 interacting genes: FEZ1 FEZ2 RAB22A RAB39A RAB39B RAB3GAP2 RPH3AL WDR7
Entrez ID		9637	22930
HPRD ID		09213	16002
Ensembl ID		ENSG00000171055	ENSG00000115839
Uniprot IDs		Q9UHY8	B9A6J2 Q15042
PDB IDs
Enriched GO Terms of Interacting Partners?
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