RAB3GAP1 and RAB3GAP2

Data Source:
BioGRID (biochemical)
HPRD (in vivo)

		RAB3GAP1	RAB3GAP2
Description		RAB3 GTPase activating protein catalytic subunit 1	RAB3 GTPase activating non-catalytic protein subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Protein-containing Complex Extracellular Exosome Endoplasmic Reticulum Tubular Network Postsynapse	Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Enzyme Activator Activity Enzyme Regulator Activity Small GTPase Binding
	Biological Process	Brain Development Hypothalamus Development Lipid Droplet Organization Camera-type Eye Development Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Short-term Neuronal Synaptic Plasticity Excitatory Postsynaptic Potential Face Morphogenesis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Autophagosome Assembly	Intracellular Protein Transport Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Protein Lipidation Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Autophagosome Assembly
Pathways		COPI-independent Golgi-to-ER retrograde traffic RAB GEFs exchange GTP for GDP on RABs	COPI-independent Golgi-to-ER retrograde traffic RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Warburg micro syndrome Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)	Martsolf syndrome
GWAS		Blood metabolite levels ( 24816252) Body mass index ( 25673413) Cholesterol, total ( 24097068 25961943 20686565) Corneal structure ( 21979947) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Sudden cardiac arrest in coronary artery disease ( 23593153)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Breast size ( 27182965)
Interacting Genes		8 interacting genes: FEZ1 FEZ2 RAB22A RAB39A RAB39B RAB3GAP2 RPH3AL WDR7	3 interacting genes: EXOSC6 FEZ1 RAB3GAP1
Entrez ID		22930	25782
HPRD ID		16002	11471
Ensembl ID		ENSG00000115839	ENSG00000118873
Uniprot IDs		B9A6J2 Q15042	Q9H2M9
PDB IDs
Enriched GO Terms of Interacting Partners?
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