RAB3GAP1 and RPH3AL

Data Source:
BioGRID (pull down)

		RAB3GAP1	RPH3AL
Description		RAB3 GTPase activating protein catalytic subunit 1	rabphilin 3A like (without C2 domains)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Protein-containing Complex Extracellular Exosome Endoplasmic Reticulum Tubular Network Postsynapse	Cytoplasm Transport Vesicle Membrane Secretory Granule Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Protein Binding Cytoskeletal Protein Binding LIM Domain Binding Metal Ion Binding
	Biological Process	Brain Development Hypothalamus Development Lipid Droplet Organization Camera-type Eye Development Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Short-term Neuronal Synaptic Plasticity Excitatory Postsynaptic Potential Face Morphogenesis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Autophagosome Assembly	Intracellular Protein Transport Exocytosis Regulation Of Exocytosis Response To Drug Positive Regulation Of Protein Secretion
Pathways		COPI-independent Golgi-to-ER retrograde traffic RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Warburg micro syndrome Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		Blood metabolite levels ( 24816252) Body mass index ( 25673413) Cholesterol, total ( 24097068 25961943 20686565) Corneal structure ( 21979947) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Sudden cardiac arrest in coronary artery disease ( 23593153)	AIDS progression ( 21502085) Dimensional psychopathology (Cognitive) ( 29496196) Idiopathic intracranial hypertension ( 29608535) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001)
Interacting Genes		8 interacting genes: FEZ1 FEZ2 RAB22A RAB39A RAB39B RAB3GAP2 RPH3AL WDR7	25 interacting genes: ANKRD11 ATPAF2 C1orf109 HNRNPK KHDRBS3 MID2 MYO15B PNMA3 PRKAB2 PSME3 RAB27A RAB27B RAB3A RAB3B RAB3C RAB3D RAB3GAP1 RAB8A RIMS2 RSPH14 SAAL1 SCNM1 TCEA3 UNC13B ZYX
Entrez ID		22930	9501
HPRD ID		16002	05345
Ensembl ID		ENSG00000115839	ENSG00000181031
Uniprot IDs		B9A6J2 Q15042	A8K7D5 Q9UNE2
PDB IDs
Enriched GO Terms of Interacting Partners?
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