TYRO3 and CTDSP2

Data Source:
BioGRID (two hybrid)

		TYRO3	CTDSP2
Description		TYRO3 protein tyrosine kinase	CTD small phosphatase 2
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex	Nucleoplasm
	Molecular Function	Virus Receptor Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol 3-kinase Binding	Phosphoprotein Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Natural Killer Cell Differentiation Phagocytosis Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neuropeptide Signaling Pathway Multicellular Organism Development Spermatogenesis Nervous System Development Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Forebrain Cell Migration Platelet Activation Secretion By Cell Positive Regulation Of Kinase Activity Negative Regulation Of Toll-like Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Ovulation Cycle Apoptotic Cell Clearance Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Innate Immune Response Viral Entry Into Host Cell Protein Autophosphorylation Negative Regulation Of Inflammatory Response Negative Regulation Of Lymphocyte Activation Vagina Development Neuron Cellular Homeostasis Platelet Aggregation Positive Regulation Of Viral Life Cycle	Negative Regulation Of Protein Phosphorylation Protein Dephosphorylation IRE1-mediated Unfolded Protein Response Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			XBP1(S) activates chaperone genes
Drugs		Fostamatinib
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Microalbuminuria ( 31511532) Red blood cell count ( 32888494) Systemic lupus erythematosus ( 24871463) Urinary albumin-to-creatinine ratio ( 31630189 31511532)	Height ( 31562340) Hematocrit ( 32888494) Metabolite levels ( 23823483) Refractive error ( 32231278) Trochanter size ( 31053729)
Interacting Genes		28 interacting genes: A2M APOE AXL CTDSP1 CTDSP2 ERBB2 FYN GAS6 GRB2 IKBKG KLK4 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 LNX1 MDFI MGAT5B PIK3R1 PROS1 SRC TNIP1 VWC2L YES1	13 interacting genes: AKT1 AR CDCA3 CSF1R EPHA1 EPHA3 INSRR LCN2 N4BP3 POLR2A PTK7 SNAI1 TYRO3
Entrez ID		7301	10106
HPRD ID		02641	12281
Ensembl ID		ENSG00000092445	ENSG00000175215
Uniprot IDs		H0YNK6 Q06418	A0A024RB65 A0A024RBA6 O14595
PDB IDs		1RHF	2Q5E
Enriched GO Terms of Interacting Partners?
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