GOSR2 and RIC3

Data Source:
BioGRID (two hybrid)

		GOSR2	RIC3
Description		golgi SNAP receptor complex member 2	RIC3 acetylcholine receptor chaperone
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane SNARE Complex Late Endosome Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Golgi Membrane Endoplasmic Reticulum Membrane Integral Component Of Membrane Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle Synapse
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding	Acetylcholine Receptor Binding Protein Folding Chaperone
	Biological Process	Protein Targeting To Vacuole Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Golgi To Vacuole Transport IRE1-mediated Unfolded Protein Response Retrograde Transport, Endosome To Golgi COPII Vesicle Coating Vesicle Fusion With Golgi Apparatus	Protein Folding Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission, Cholinergic Protein Localization To Cell Surface Cellular Protein-containing Complex Assembly
Pathways		COPII-mediated vesicle transport XBP1(S) activates chaperone genes Cargo concentration in the ER COPI-mediated anterograde transport Intra-Golgi traffic
Drugs			Theophylline
Diseases
GWAS		Aortic root size ( 28394258) Atrial fibrillation ( 29892015) Blood pressure ( 21909110) Blood urea nitrogen levels ( 31152163 29403010) Body mass index ( 26426971) Cleft lip with or without cleft palate ( 28054174) Coronary artery disease ( 29212778 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Feeling guilty ( 29500382) Feeling worry ( 29500382) Hemoglobin levels ( 32327693) Idiopathic pulmonary fibrosis ( 29066090) Ischemic stroke ( 29930801) Mean arterial pressure ( 27618448) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Myocardial infarction ( 30226566) Nonsyndromic cleft lip with cleft palate ( 28232668) Orofacial clefts ( 28054174) Pulse pressure ( 27841878 28739976 30578418) QRS duration ( 27577874 30012220 21076409) QT interval ( 29874175) Systolic blood pressure ( 28135244 27841878 21909115 28739976 27618447 27618452 30578418)	Blood protein levels ( 30072576) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Malaria ( 31844061)
Interacting Genes		51 interacting genes: APP AQP6 ARF1 ARL13B BET1 BLCAP CREB3L1 CYB561 CYBRD1 EBP ELOVL4 ELOVL5 FAM174A FAM209A FATE1 GOLGA8EP GOLGA8F GPR152 GPR42 GPX8 HIBADH HSD17B13 IER3IP1 JAGN1 KASH5 LEUTX LIME1 LMNA MARCHF8 MFF MFSD14B MFSD5 NAPA PELI1 RETREG3 RIC3 RNF19B SLC10A1 SLC10A6 SPAG4 STX1A STX4 STX5 TLCD4 TM4SF19 TMCO5A TMEM106A TMEM106C TMEM205 TMEM35A USO1	15 interacting genes: BCL2L1 CLN6 FA2H FATE1 GOSR2 NINJ2 PRB1 STX12 STX7 TMBIM1 TMEFF2 TMEM11 TMEM86A TRAF3IP3 YIF1A
Entrez ID		9570	79608
HPRD ID		04937	17974
Ensembl ID		ENSG00000108433	ENSG00000166405
Uniprot IDs		A0A1W2PQE0 A0A1W2PQM3 A0A1W2PR02 A0A1W2PRL0 I3NI02 O14653	A0A0S2Z607 A0A0S2Z6D3 B7Z3Z0 D3DQU6 Q7Z5B4
PDB IDs		3EG9
Enriched GO Terms of Interacting Partners?
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