GOSR2 and ELOVL5

Data Source:
BioGRID (two hybrid)

		GOSR2	ELOVL5
Description		golgi SNAP receptor complex member 2	ELOVL fatty acid elongase 5
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane SNARE Complex Late Endosome Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane Dendrite Neuronal Cell Body Dendritic Tree
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding	Protein Binding Fatty Acid Elongase Activity 3-oxo-arachidoyl-CoA Synthase Activity 3-oxo-cerotoyl-CoA Synthase Activity 3-oxo-lignoceronyl-CoA Synthase Activity Very-long-chain 3-ketoacyl-CoA Synthase Activity
	Biological Process	Protein Targeting To Vacuole Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Golgi To Vacuole Transport IRE1-mediated Unfolded Protein Response Retrograde Transport, Endosome To Golgi COPII Vesicle Coating Vesicle Fusion With Golgi Apparatus	Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process
Pathways		COPII-mediated vesicle transport XBP1(S) activates chaperone genes Cargo concentration in the ER COPI-mediated anterograde transport Intra-Golgi traffic	Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Synthesis of very long-chain fatty acyl-CoAs
Drugs			alpha-Linolenic acid
Diseases
GWAS		Aortic root size ( 28394258) Atrial fibrillation ( 29892015) Blood pressure ( 21909110) Blood urea nitrogen levels ( 31152163 29403010) Body mass index ( 26426971) Cleft lip with or without cleft palate ( 28054174) Coronary artery disease ( 29212778 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Feeling guilty ( 29500382) Feeling worry ( 29500382) Hemoglobin levels ( 32327693) Idiopathic pulmonary fibrosis ( 29066090) Ischemic stroke ( 29930801) Mean arterial pressure ( 27618448) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Myocardial infarction ( 30226566) Nonsyndromic cleft lip with cleft palate ( 28232668) Orofacial clefts ( 28054174) Pulse pressure ( 27841878 28739976 30578418) QRS duration ( 27577874 30012220 21076409) QT interval ( 29874175) Systolic blood pressure ( 28135244 27841878 21909115 28739976 27618447 27618452 30578418)	Cerebrospinal fluid AB1-42 levels ( 26252872) Daytime sleep phenotypes ( 27126917) Familial squamous cell lung carcinoma ( 29924316) Glaucoma ( 20363506) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Red cell distribution width ( 32888494) Survival in colorectal cancer (distant metastatic) ( 26586795)
Interacting Genes		51 interacting genes: APP AQP6 ARF1 ARL13B BET1 BLCAP CREB3L1 CYB561 CYBRD1 EBP ELOVL4 ELOVL5 FAM174A FAM209A FATE1 GOLGA8EP GOLGA8F GPR152 GPR42 GPX8 HIBADH HSD17B13 IER3IP1 JAGN1 KASH5 LEUTX LIME1 LMNA MARCHF8 MFF MFSD14B MFSD5 NAPA PELI1 RETREG3 RIC3 RNF19B SLC10A1 SLC10A6 SPAG4 STX1A STX4 STX5 TLCD4 TM4SF19 TMCO5A TMEM106A TMEM106C TMEM205 TMEM35A USO1	16 interacting genes: C2CD2L GOSR2 HMOX1 HMOX2 HTR4 IGFBP5 NINJ2 PLP2 SLC39A9 STX7 SYNJ2BP SYS1 THSD7A TMEM243 TSNARE1 UBC
Entrez ID		9570	60481
HPRD ID		04937	13268
Ensembl ID		ENSG00000108433	ENSG00000012660
Uniprot IDs		A0A1W2PQE0 A0A1W2PQM3 A0A1W2PR02 A0A1W2PRL0 I3NI02 O14653	A0A024RD35 A0A0A0MTI6 B3KWH9 Q9NYP7
PDB IDs		3EG9
Enriched GO Terms of Interacting Partners?
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