PTGES and TMEM65

Data Source:
BioGRID (two hybrid)

		PTGES	TMEM65
Description		prostaglandin E synthase	transmembrane protein 65
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Lumen Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Mitochondrial Inner Membrane Plasma Membrane Intercalated Disc Integral Component Of Membrane
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Prostaglandin-D Synthase Activity Protein Binding Glutathione Binding Prostaglandin-E Synthase Activity	Protein Binding
	Biological Process	Prostaglandin Biosynthetic Process Acute Inflammatory Response Chronic Inflammatory Response Prostaglandin Metabolic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Organic Cyclic Compound Sensory Perception Of Pain Cyclooxygenase Pathway Regulation Of Fever Generation Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Response To Retinoic Acid Response To Cytokine Regulation Of Inflammatory Response Response To Calcium Ion Cellular Oxidant Detoxification	Cardiac Ventricle Development Regulation Of Cardiac Conduction
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs
Diseases
GWAS		Asthma ( 27611488) Pars orbitalis volume ( 31530798)	Fear of minor pain ( 28701861)
Interacting Genes		18 interacting genes: BET1 C4orf3 EHHADH GIMAP1 GIMAP5 PLP2 PTGER1 PTGER2 SEC22A SERP2 SMCO4 TMEM19 TMEM222 TMEM65 VAMP3 VAMP4 VAPB YIF1A	33 interacting genes: ABHD16A AQP6 ARL13B CYB561 CYBRD1 EBP ERGIC3 FAM174A FAM209A GJA8 GPR42 HSD17B11 IGSF9 IL3RA JAGN1 JPH1 LMNA MSMO1 PDZK1IP1 PTGES PVR REEP4 RETREG3 SCN3B SLC10A6 SLC18A1 SLC35C2 SLC7A8 TIMMDC1 TMEM101 TMEM80 TMX2 ZFYVE27
Entrez ID		9536	157378
HPRD ID		05528	14102
Ensembl ID		ENSG00000148344	ENSG00000164983
Uniprot IDs		O14684	Q6PI78
PDB IDs		3DWW 4AL0 4AL1 4BPM 4WAB 4YK5 4YL0 4YL1 4YL3 5BQG 5BQH 5BQI 5K0I 5T36 5T37 5TL9
Enriched GO Terms of Interacting Partners?
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