ACY1 and BCAS2

Data Source:
BioGRID (two hybrid)

		ACY1	BCAS2
Description		aminoacylase 1	BCAS2 pre-mRNA processing factor
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Nucleolus Centrosome Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Aminoacylase Activity Protein Binding Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Cellular Amino Acid Metabolic Process Xenobiotic Metabolic Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing
Pathways		Aflatoxin activation and detoxification Defective ACY1 causes encephalopathy	mRNA Splicing - Major Pathway
Drugs		Aspartic acid Acetylcysteine Copper
Diseases
GWAS			Autism ( 24189344) Chronotype ( 30696823)
Interacting Genes		12 interacting genes: APP BCAS2 NPM1 NTAQ1 NUDT1 POT1 PRR35 TENT5B TERF1 TLX3 TTC1 WWOX	61 interacting genes: ACY1 AIMP2 BLK C10orf82 C9orf24 CCDC120 CCDC17 ECM1 EMILIN3 ENKD1 EP300 ESR1 ESR2 FAM86C1P GOLGA2 HGS HSF2BP IFI35 IKZF3 KRT20 KRT27 KRT31 KRT34 KRT35 KRT36 KRT37 KRT40 KRT75 KRTAP19-6 KRTAP8-1 LMO1 LMO2 LMO3 LMO4 MED29 MIIP MYOZ3 OIP5 PAX5 PCBD2 PFDN5 PGR PLAGL2 PLEKHF2 POT1 PPARG PPP1R32 SF1 SMARCD1 SNRNP200 SNRPC TCF4 TCHP TP53BP2 TRAF1 TXN2 TXNRD2 UBC USHBP1 YPEL3 ZWINT
Entrez ID		95	10286
HPRD ID		00092	05777
Ensembl ID		ENSG00000243989	ENSG00000116752
Uniprot IDs		Q03154 V9HWA0	B2R7W3 O75934
PDB IDs		1Q7L	5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P
Enriched GO Terms of Interacting Partners?
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