ARHGEF6 and PARVB

Data Source:
HPRD (two hybrid, in vitro)

		ARHGEF6	PARVB
Description		Rac/Cdc42 guanine nucleotide exchange factor 6	parvin beta
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GO Annotations	Cellular Component	Cytosol Lamellipodium	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Actin Binding Protein Binding
	Biological Process	Apoptotic Process G Protein-coupled Receptor Signaling Pathway JNK Cascade Lamellipodium Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Establishment Or Maintenance Of Cell Polarity Cell Projection Assembly Lamellipodium Assembly Actin Cytoskeleton Reorganization Substrate Adhesion-dependent Cell Spreading Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42	Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs
Diseases		Non-syndromic X-linked mental retardation
GWAS		Breast cancer ( 29059683)	Alzheimer's disease (cognitive decline) ( 23535033) Hematological and biochemical traits ( 20139978) Lewy body disease ( 25188341) Nonalcoholic fatty liver disease ( 22719876) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Response to chemotherapy in breast cancer (hypertension) (bevacizumab) ( 25117820) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Systemic sclerosis (anti-centromere-positive) ( 29293537)
Interacting Genes		37 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CBFA2T3 CCDC33 CDC42 EPHB2 GIT1 GIT2 GOLGA2 GPRASP2 HSF2BP KRT27 NUTM1 PAK1 PAK2 PAK3 PARVB PNMA1 POU6F2 RWDD2A SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 TP53BP2 TRAF2 TRIM54 YWHAG ZNF580	2 interacting genes: ARHGEF6 ILK
Entrez ID		9459	29780
HPRD ID		02226	16284
Ensembl ID		ENSG00000129675	ENSG00000188677
Uniprot IDs		B7Z3C7 Q15052 Q8N4Q3	A0A087WZB5 Q9HBI1
PDB IDs		1UJY 1WYR	4EDL 4EDM 4EDN
Enriched GO Terms of Interacting Partners?
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