HOMER1 and DNM3

Data Source:
HPRD (in vitro)

		HOMER1	DNM3
Description		homer scaffold protein 1	dynamin 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Z Disc Axon Dendrite Costamere Dendritic Spine Neuron Spine Apical Part Of Cell Glutamatergic Synapse Postsynaptic Cytosol	Cytoplasm Golgi Apparatus Microtubule Plasma Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Axon Cytoplasmic Vesicle Mitochondrial Membrane Synaptic Cleft Dendritic Spine Dendritic Spine Head Perinuclear Region Of Cytoplasm Apical Tubulobulbar Complex Basal Tubulobulbar Complex Extracellular Exosome Presynapse Postsynaptic Endocytic Zone Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding G Protein-coupled Glutamate Receptor Binding Signaling Adaptor Activity Ion Channel Binding	GTPase Activity Protein Binding GTP Binding Microtubule Binding Type 1 Metabotropic Glutamate Receptor Binding Type 5 Metabotropic Glutamate Receptor Binding Nitric-oxide Synthase Binding Structural Constituent Of Postsynapse
	Biological Process	Skeletal Muscle Contraction Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Behavioral Response To Cocaine Skeletal Muscle Fiber Development Chemical Homeostasis Within A Tissue Protein Tetramerization Response To Calcium Ion Positive Regulation Of Calcium Ion Transport Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Calcium Ion Import Regulation Of Postsynaptic Neurotransmitter Receptor Activity Regulation Of Dendritic Spine Maintenance Regulation Of Store-operated Calcium Entry Regulation Of Cation Channel Activity	Mitochondrial Fission Dynamin Family Protein Polymerization Involved In Mitochondrial Fission Endocytosis Synapse Assembly Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Receptor Internalization Filopodium Assembly Regulation Of Synapse Structure Or Activity Positive Regulation Of Filopodium Assembly Negative Regulation Of Dendritic Spine Morphogenesis Membrane Fusion Postsynaptic Neurotransmitter Receptor Internalization Postsynapse Organization Positive Regulation Of Synaptic Vesicle Recycling
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling MHC class II antigen presentation Recycling pathway of L1 Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Blood and toenail selenium levels ( 25343990) Height ( 18193045) Hepcidin/ferritin ratio ( 27846281) Lateral ventricle temporal horn volume ( 31530798) Major depressive disorder ( 20673876) Metabolite levels ( 23823483) Toenail selenium levels ( 25343990)	Diastolic blood pressure ( 28135244 27841878) Estimated glomerular filtration rate ( 31152163) Femoral neck bone mineral density ( 22504420) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 25429064 23563607 31562340 18391951) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 29083408) Hip circumference adjusted for BMI ( 25673412) Mean platelet volume ( 22139419 24026423 19820697 32888494 27863252) Ovarian cancer ( 30557369) Platelet count ( 22139419 29403010 32888494 27863252) Platelet distribution width ( 32888494 27863252) QT interval (sulfonylurea treatment interaction) ( 27958378) Red blood cell count ( 32888494) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Uterine fibroids ( 31249589) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		34 interacting genes: ABI1 ABI3 AGAP2 AIMP1 BRME1 C1orf116 CENPQ DBNL DNM3 EFNB2 FAM9A FAT1 FCHSD2 GRIA1 GRIK1 GRM1 GRM5 HOMER3 ITPR1 NUP54 PATJ PIAS2 RAD54L2 RASAL3 RYR1 RYR2 SHANK1 SHANK2 STX12 SYCE2 TANC1 TRAF5 TRPC1 ZMYM5	2 interacting genes: DYNLL1 HOMER1
Entrez ID		9456	26052
HPRD ID		09211	13241
Ensembl ID		ENSG00000152413	ENSG00000197959
Uniprot IDs		Q5U5K4 Q86YM7	Q9UQ16
PDB IDs			3L43 5A3F
Enriched GO Terms of Interacting Partners?
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