GGPS1 and ATOX1

Data Source:
BioGRID (two hybrid)

		GGPS1	ATOX1
Description		geranylgeranyl diphosphate synthase 1	antioxidant 1 copper chaperone
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GO Annotations	Cellular Component	Cytosol	Cytosol
	Molecular Function	Dimethylallyltranstransferase Activity Farnesyltranstransferase Activity Geranyltranstransferase Activity Prenyltransferase Activity Protein Binding Identical Protein Binding Metal Ion Binding	Copper Ion Binding Protein Binding Metallochaperone Activity Copper Chaperone Activity Copper-dependent Protein Binding
	Biological Process	Cholesterol Biosynthetic Process Isoprenoid Metabolic Process Isoprenoid Biosynthetic Process Geranyl Diphosphate Biosynthetic Process Geranylgeranyl Diphosphate Biosynthetic Process Farnesyl Diphosphate Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process	Copper Ion Transport Cellular Copper Ion Homeostasis Response To Oxidative Stress
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface
Drugs		Pamidronic acid Zoledronic acid Ibandronate Geranyl Diphosphate Farnesyl thiopyrophosphate ISOPENTENYL PYROPHOSPHATE Minodronic acid (1-HYDROXYHEPTANE-1,1-DIYL)BIS(PHOSPHONIC ACID) (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID) (2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUM [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate Lauryl alcohol diphosphonic acid (6E,11E)-HEPTADECA-6,11-DIENE-9,9-DIYLBIS(PHOSPHONIC ACID)	Cisplatin Sucrose Benzamidine
Diseases
GWAS		Asthma ( 29273806)	Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) Red cell distribution width ( 32888494) Systolic blood pressure change trajectories ( 27980656)
Interacting Genes		2 interacting genes: ATOX1 SDCBP	8 interacting genes: ATP7A ATP7B CFAP410 COMP FAM118A FKBP4 GGPS1 NECAB1
Entrez ID		9453	475
HPRD ID		06099	03779
Ensembl ID		ENSG00000152904	ENSG00000177556
Uniprot IDs		A0A024R3R2 O95749	O00244
PDB IDs		2Q80 6C56 6C57 6G31 6G32 6R4V	1FE0 1FE4 1FEE 1TL4 1TL5 2K1R 2LQ9 3CJK 3IWL 3IWX 4QOT 4YDX 4YEA 5F0W 5T7L
Enriched GO Terms of Interacting Partners?
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