ATOX1 and COMP

Data Source:
BioGRID (two hybrid)

		ATOX1	COMP
Description		antioxidant 1 copper chaperone	cartilage oligomeric matrix protein
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GO Annotations	Cellular Component	Cytosol	Extracellular Region Extracellular Space Extracellular Matrix Protein-containing Complex Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Copper Ion Binding Protein Binding Metallochaperone Activity Copper Chaperone Activity Copper-dependent Protein Binding	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Heparin Binding BMP Binding Proteoglycan Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Copper Ion Transport Cellular Copper Ion Homeostasis Response To Oxidative Stress	Skeletal System Development Chondrocyte Development Growth Plate Cartilage Development Apoptotic Process Response To Unfolded Protein Protein Secretion Animal Organ Morphogenesis Multicellular Organism Aging Animal Organ Senescence Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Protein Processing Extracellular Matrix Organization Collagen Fibril Organization Bone Mineralization Regulation Of Bone Mineralization BMP Signaling Pathway Multicellular Organism Growth Chondrocyte Proliferation Tendon Development Negative Regulation Of Apoptotic Process Skin Development Muscle Fiber Development Artery Morphogenesis Musculoskeletal Movement Neuromuscular Process Limb Development Platelet Aggregation Vascular Associated Smooth Muscle Cell Development Negative Regulation Of Hemostasis Positive Regulation Of Chondrocyte Proliferation
Pathways		Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface	Integrin cell surface interactions ECM proteoglycans
Drugs		Cisplatin Sucrose Benzamidine	Calcium
Diseases			Pseudoachondroplasia (PSACH) Multiple epiphyseal dysplasia (MED)
GWAS		Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) Red cell distribution width ( 32888494) Systolic blood pressure change trajectories ( 27980656)	Osteoarthritis (with total hip replacement) ( 28319091) Osteoarthritis biomarkers ( 25057126) QT interval ( 29213071)
Interacting Genes		8 interacting genes: ATP7A ATP7B CFAP410 COMP FAM118A FKBP4 GGPS1 NECAB1	10 interacting genes: AQP1 ATOX1 COL2A1 COL9A1 CYSRT1 FN1 MEOX2 NUFIP2 OTX1 SGTB
Entrez ID		475	1311
HPRD ID		03779	02632
Ensembl ID		ENSG00000177556	ENSG00000105664
Uniprot IDs		O00244	P49747
PDB IDs		1FE0 1FE4 1FEE 1TL4 1TL5 2K1R 2LQ9 3CJK 3IWL 3IWX 4QOT 4YDX 4YEA 5F0W 5T7L	3FBY
Enriched GO Terms of Interacting Partners?
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