AIM2 and ANP32B

Data Source:
BioGRID (two hybrid)

		AIM2	ANP32B
Description		absent in melanoma 2	acidic nuclear phosphoprotein 32 family member B
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol AIM2 Inflammasome Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Extracellular Exosome
	Molecular Function	Double-stranded DNA Binding Protein Binding Identical Protein Binding	Protein Binding Histone Binding RNA Polymerase Binding
	Biological Process	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Apoptotic Process Inflammatory Response Immune Response Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Interleukin-1 Beta Production Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Interferon-beta Cellular Response To Drug NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Pyroptosis Pyroptosome Complex Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity	Vasculature Development Nucleosome Assembly Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Ventricular System Development Regulation Of Apoptotic Process Negative Regulation Of Cell Differentiation Positive Regulation Of Protein Export From Nucleus Inner Ear Development Roof Of Mouth Development
Pathways		The AIM2 inflammasome The AIM2 inflammasome
Drugs
Diseases
GWAS		Neutrophil count in HIV-infection ( 25884002) Obesity-related traits ( 23251661) Psoriasis ( 25854761)	Alopecia areata ( 25608926) Coronary artery disease ( 29212778) Eosinophil counts ( 32888494) Immature fraction of reticulocytes ( 27863252) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Serum thyroid-stimulating hormone levels ( 25436638)
Interacting Genes		3 interacting genes: ANP32B APPBP2 RNF4	43 interacting genes: AIM2 APC APP AURKA BAX BCL10 BEND7 BUB1 CHAF1A CSNK2A1 DCC DNTTIP1 ELAVL1 ESR1 FAM217B FAM3A FBXW7 H2AC1 H2BC1 H3C1 H4C1 HNF4A KLF5 KPNA1 KPNA5 KPNA6 MCC MEOX2 MLH3 MYNN PMS2 POLR1A PTEN PTPN12 PTPRJ SDCBP SMAD2 SMARCD1 STK11 TLR2 UCHL5 XPO1 YAF2
Entrez ID		9447	10541
HPRD ID		05202	09803
Ensembl ID		ENSG00000163568	ENSG00000136938
Uniprot IDs		O14862	Q92688
PDB IDs		3RN2 3RN5 3VD8 4O7Q 6MB2	2ELL 2RR6
Enriched GO Terms of Interacting Partners?
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