ANP32B and AIM2

Data Source:
BioGRID (two hybrid)

		ANP32B	AIM2
Description		acidic nuclear phosphoprotein 32 family member B	absent in melanoma 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Extracellular Exosome	Nucleoplasm Cytoplasm Mitochondrion Cytosol AIM2 Inflammasome Complex
	Molecular Function	Protein Binding Histone Binding RNA Polymerase Binding	Double-stranded DNA Binding Protein Binding Identical Protein Binding
	Biological Process	Vasculature Development Nucleosome Assembly Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Ventricular System Development Regulation Of Apoptotic Process Negative Regulation Of Cell Differentiation Positive Regulation Of Protein Export From Nucleus Inner Ear Development Roof Of Mouth Development	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Apoptotic Process Inflammatory Response Immune Response Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Interleukin-1 Beta Production Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Interferon-beta Cellular Response To Drug NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Pyroptosis Pyroptosome Complex Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways			The AIM2 inflammasome The AIM2 inflammasome
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Coronary artery disease ( 29212778) Eosinophil counts ( 32888494) Immature fraction of reticulocytes ( 27863252) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Serum thyroid-stimulating hormone levels ( 25436638)	Neutrophil count in HIV-infection ( 25884002) Obesity-related traits ( 23251661) Psoriasis ( 25854761)
Interacting Genes		43 interacting genes: AIM2 APC APP AURKA BAX BCL10 BEND7 BUB1 CHAF1A CSNK2A1 DCC DNTTIP1 ELAVL1 ESR1 FAM217B FAM3A FBXW7 H2AC1 H2BC1 H3C1 H4C1 HNF4A KLF5 KPNA1 KPNA5 KPNA6 MCC MEOX2 MLH3 MYNN PMS2 POLR1A PTEN PTPN12 PTPRJ SDCBP SMAD2 SMARCD1 STK11 TLR2 UCHL5 XPO1 YAF2	3 interacting genes: ANP32B APPBP2 RNF4
Entrez ID		10541	9447
HPRD ID		09803	05202
Ensembl ID		ENSG00000136938	ENSG00000163568
Uniprot IDs		Q92688	O14862
PDB IDs		2ELL 2RR6	3RN2 3RN5 3VD8 4O7Q 6MB2
Enriched GO Terms of Interacting Partners?
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