GRAP2 and WWP2

Data Source:
BioGRID (two hybrid)

		GRAP2	WWP2
Description		GRB2 related adaptor protein 2	WW domain containing E3 ubiquitin protein ligase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Factor Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ras Protein Signal Transduction Cell-cell Signaling T Cell Costimulation Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Cellular Protein Modification Process Extracellular Transport Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity
Pathways		Signaling by SCF-KIT Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 co-stimulation FLT3 Signaling	Regulation of PTEN stability and activity NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Body mass index ( 26426971) Systemic lupus erythematosus ( 28714469)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 28552196 31562340) IgE levels ( 23146381) Knee osteoarthritis ( 30374069) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FVC) ( 30804560) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Menarche (age at onset) ( 25231870) Plantar fascial disorders ( 29534260) Platelet count ( 32888494) Pulse pressure ( 30578418) Smoking behaviour (cigarette pack-years) ( 30679032) Triglyceride levels ( 31928498) Triglycerides ( 30275531) Waist circumference ( 31928498)
Interacting Genes		79 interacting genes: AR BAG4 BEND5 BLNK CBL CBLB CBY2 CCHCR1 CCNDBP1 CD28 COG6 CSF1R DNM2 DVL2 EGFR ERBB2 ERBB3 ERBB4 ETV5 FASLG GAB1 GAB2 GAB3 GAREM1 GATA1 GFAP GOLGA2 GRB2 HNRNPK IHO1 IKZF3 KHDRBS1 KHDRBS2 KIT KPRP KRT13 KRTAP1-3 KRTAP4-11 KRTAP4-12 LAT LATS2 LAX1 LCP2 LNX1 LNX2 MAGED1 MAP4K1 MKRN3 MOS MTUS2 PBLD PNMA1 PRKAA2 PRPH2 PRR35 RACK1 RAVER1 RBPMS RIN3 RINT1 SH2D4A SHB SHC1 SOS2 SPRY2 SSX2IP STAMBP TFIP11 TLE5 TRAF1 TSNAXIP1 USP8 WWP2 YWHAE ZBTB7B ZNF250 ZNF319 ZNF526 ZSCAN21	79 interacting genes: ANKRD44 ARRDC1 ARRDC3 ATN1 CDC34 CLCN5 CPSF6 DAG1 DIDO1 EFCAB3 EGR2 EWSR1 FAM189A2 FAM214B FBXL18 GADD45GIP1 GAS2L2 GGN GRAP2 HNRNPUL1 IFIT2 IL2RG IL6R LGALS9B MED25 MIR19A MIR19B1 MIR92A1 NDFIP1 NDFIP2 PAIP1 PATZ1 PDLIM7 PRKAA2 PSMF1 RASA1 RASD1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEC24D SF1 SFTPC SLC9A3R2 SMAD3 SMAD7 SMARCD1 SMR3A SNRPB SNRPC SPART TFAP2A TNK2 TP53BP2 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2J2 UBE2K UBE2L3 UBTD1 USP7 VASP VPS37C WBP1 WBP2 WDR5 WIPF1 ZNF688
Entrez ID		9402	11060
HPRD ID		05156	03812
Ensembl ID		ENSG00000100351	ENSG00000198373
Uniprot IDs		B7Z8E3 O75791 Q6FI14	A0A024R711 B4DHF6 O00308
PDB IDs		5GJH	4Y07 5TJ7 5TJ8 5TJQ 6J1Z 6RSS
Enriched GO Terms of Interacting Partners?
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