SLIT2 and ROBO2

Data Source:
HPRD (in vitro)

		SLIT2	ROBO2
Description		slit guidance ligand 2	roundabout guidance receptor 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Membrane Extracellular Exosome	Plasma Membrane Cell Surface Integral Component Of Membrane Axolemma Extracellular Exosome
	Molecular Function	GTPase Inhibitor Activity Calcium Ion Binding Protein Binding Heparin Binding Identical Protein Binding Protein Homodimerization Activity Laminin-1 Binding Proteoglycan Binding Roundabout Binding	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding
	Biological Process	Ureteric Bud Development Negative Regulation Of Protein Phosphorylation Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Leukocyte Chemotaxis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Axon Guidance Motor Neuron Axon Guidance Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Smooth Muscle Cell Migration Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Corticospinal Neuron Axon Guidance Through Spinal Cord Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of Actin Filament Polymerization Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Negative Regulation Of GTPase Activity Roundabout Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Branching Morphogenesis Of An Epithelial Tube Axon Extension Involved In Axon Guidance Positive Regulation Of Axonogenesis Negative Chemotaxis Induction Of Negative Chemotaxis Negative Regulation Of Small GTPase Mediated Signal Transduction Response To Cortisol Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway Cellular Response To Heparin Negative Regulation Of Smooth Muscle Cell Chemotaxis Negative Regulation Of Mononuclear Cell Migration Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Cellular Response To Growth Factor Stimulus	Metanephros Development Ureteric Bud Development Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Olfactory Bulb Interneuron Development Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Positive Regulation Of Notch Signaling Pathway Involved In Heart Induction Aorta Development Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis
Pathways		Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Activation of RAC1 Regulation of commissural axon pathfinding by SLIT and ROBO Inactivation of CDC42 and RAC1 Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling SLIT2:ROBO1 increases RHOA activity Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs	Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs ROBO receptors bind AKAP5
Drugs
Diseases			Vesicoureteral reflux
GWAS		Adult body size ( 32376654) Body mass index ( 31453325) Body mass index variance ( 31453325) Early spontaneous preterm birth ( 31194736) Echocardiographic traits ( 17903301) Gestational age at birth (child effect) ( 31194736) Pars orbitalis volume ( 31530798) QRS duration ( 27659466) Response to long-chain n-3 polyunsaturated fatty acid supplementation (change in triglyceride levels) ( 24847101) Serum metabolite concentrations in chronic kidney disease ( 29545352)	Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Expressive vocabulary in infants ( 25226531) Familial lung adenocarcinoma ( 29924316) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Hand grip strength ( 29691431) Hip circumference ( 28552196) Left-handedness ( 32989287) Metabolite levels ( 23823483) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Morning person ( 30696823) Periodontitis (PAL4Q3) ( 24024966) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to ketamine in bipolar disorder or major depression (dissociation effects) ( 30552317) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30297969)
Interacting Genes		4 interacting genes: GPC1 ROBO1 ROBO2 UBC	18 interacting genes: BNIP3L CENPU CPE GPR152 HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TMEM237 TRIM13 UBQLN4
Entrez ID		9353	6092
HPRD ID		04776	11895
Ensembl ID		ENSG00000145147	ENSG00000185008
Uniprot IDs		O94813	Q9HCK4
PDB IDs		2V70 2V9S 2V9T 2WFH	1UEM 1UJT 2EDJ 5NOI 6I9S 6IAA
Enriched GO Terms of Interacting Partners?
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