CD22 and ANKRD46

Data Source:
BioGRID (two hybrid)

		CD22	ANKRD46
Description		CD22 molecule	ankyrin repeat domain 46
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Neuronal Cell Body Membrane Recycling Endosome Extracellular Exosome	Integral Component Of Membrane
	Molecular Function	IgM Binding Signaling Receptor Binding Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding CD4 Receptor Binding
	Biological Process	Negative Regulation Of Immunoglobulin Production Cell Adhesion Regulation Of Endocytosis Regulation Of B Cell Proliferation B Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of B Cell Receptor Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Epratuzumab Inotuzumab ozogamicin Moxetumomab Pasudotox
Diseases
GWAS		Red cell distribution width ( 32888494)	Atrioventricular conduction ( 21041692) Body mass index ( 26426971) Percentage gas trapping ( 26030696)
Interacting Genes		20 interacting genes: ANKRD46 AP2M1 ATP2B4 CD19 GRB2 HP IGHM INPP5D LCP2 LYN MTDH NTAQ1 PIK3R1 PLCG1 PTPN6 PTPRC SHC1 ST6GAL1 SYK TMEM140	61 interacting genes: AMIGO1 APH1A AQP6 ARL13B BIK BSCL2 C16orf54 CD22 CD46 CLDN20 CLDN7 CLEC4D CRB3 CREB3L1 CXADR CYB561 EBP EFNB1 EFNB2 ELOVL4 FAM174A FAM209A GOLM1 GPR152 GPR42 HSD17B11 HSD17B13 IFNLR1 KASH5 KIR2DL3 LAMTOR5 LDLRAD1 LRRC25 MFF MMGT1 MUC1 NCAPH2 NSG2 PLPP4 PVR RELL2 RETREG3 SCN3B SECTM1 SHISA3 SLC10A6 SLC16A2 SLC18A1 SLC39A9 ST6GALNAC6 STX1A STX2 STX4 SUSD3 THAP4 TIMMDC1 TMEM248 TMEM31 TMEM45B TMEM79 TMPRSS2
Entrez ID		933	157567
HPRD ID		00114	14103
Ensembl ID		ENSG00000012124	ENSG00000186106
Uniprot IDs		P20273 Q0EAF5	A0A024R9E1 A0A024R9G2 B3KT99 Q86W74
PDB IDs		5VKJ 5VKM 5VL3
Enriched GO Terms of Interacting Partners?
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