CD22 and ST6GAL1

Data Source:
HPRD (in vitro)

		CD22	ST6GAL1
Description		CD22 molecule	ST6 beta-galactoside alpha-2,6-sialyltransferase 1
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GO Annotations	Cellular Component	Cytoplasm Early Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Neuronal Cell Body Membrane Recycling Endosome Extracellular Exosome	Golgi Membrane Extracellular Region Integral Component Of Membrane Golgi Cisterna Membrane
	Molecular Function	IgM Binding Signaling Receptor Binding Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding CD4 Receptor Binding	Beta-galactoside Alpha-2,6-sialyltransferase Activity Protein Binding Sialyltransferase Activity Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Immunoglobulin Production Cell Adhesion Regulation Of Endocytosis Regulation Of B Cell Proliferation B Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of B Cell Receptor Signaling Pathway	N-acetylneuraminate Metabolic Process Humoral Immune Response O-glycan Processing Protein N-linked Glycosylation Via Asparagine Sialylation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Sialic acid metabolism Maturation of protein 3a Maturation of spike protein Maturation of protein 3a N-Glycan antennae elongation Termination of O-glycan biosynthesis
Drugs		Epratuzumab Inotuzumab ozogamicin Moxetumomab Pasudotox
Diseases
GWAS		Red cell distribution width ( 32888494)	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Albumin-globulin ratio ( 29403010) Blood protein levels ( 29875488) Drug-induced liver injury (flucloxacillin) ( 19483685) Eosinophil percentage of white cells ( 32888494) Esophageal cancer (squamous cell) ( 22960999) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) IgA nephropathy ( 26028593) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG monosialylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Immature fraction of reticulocytes ( 32888494) N-glycan levels ( 31163085) Non-albumin protein levels ( 29403010) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132) Thyroglobulin plasma levels ( 30929638) Type 2 diabetes ( 30054458 21874001 30297969 32499647 30718926)
Interacting Genes		20 interacting genes: ANKRD46 AP2M1 ATP2B4 CD19 GRB2 HP IGHM INPP5D LCP2 LYN MTDH NTAQ1 PIK3R1 PLCG1 PTPN6 PTPRC SHC1 ST6GAL1 SYK TMEM140	1 interacting genes: CD22
Entrez ID		933	6480
HPRD ID		00114	00184
Ensembl ID		ENSG00000012124	ENSG00000073849
Uniprot IDs		P20273 Q0EAF5	P15907
PDB IDs		5VKJ 5VKM 5VL3	4JS1 4JS2 6QVS 6QVT
Enriched GO Terms of Interacting Partners?
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