UBE2Q2 and RNF111

Data Source:
BioGRID (two hybrid)

		UBE2Q2	RNF111
Description		ubiquitin conjugating enzyme E2 Q2	ring finger protein 111
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GO Annotations	Cellular Component	Nucleus Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Protein-containing Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding SUMO Polymer Binding SMAD Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Pattern Specification Process Protein Ubiquitination Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Global Genome Nucleotide-excision Repair
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Formation of Incision Complex in GG-NER Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Estimated glomerular filtration rate ( 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494) Urate levels ( 31985003 23263486) Urate levels in obese individuals ( 25811787)	Apolipoprotein A1 levels ( 32203549) Asperger disorder ( 21182207) Atopic dermatitis ( 25865352) Cerebrospinal fluid AB1-42 levels ( 28247064) Metabolite levels ( 22916037) Social communication problems ( 24047820)
Interacting Genes		10 interacting genes: BIRC2 BIRC3 ITCH MDM2 PCGF2 RC3H2 RNF111 RNF31 UBA1 UBC	54 interacting genes: ACTN3 ANAPC11 AP2M1 AXIN1 CREB1 CREBBP CSNK2A1 CTBP1 DTX3L EDARADD KRTAP1-1 KRTAP5-9 LCE4A LRSAM1 MARCHF7 MDFI MVP NBPF19 NOTCH2NLA PAX6 PHF7 PML PSME3 PTPN3 SDCBP2 SMAD3 SMAD6 SMAD7 SMURF2 SUMO1 SUMO2 SUMO3 TRAF5 TRIM21 TRIM8 TSG101 TSPYL1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2M UBE2N UBE2Q2 UBE2V1 UBE2W VAPB
Entrez ID		92912	54778
HPRD ID		14294	09318
Ensembl ID		ENSG00000140367	ENSG00000157450
Uniprot IDs		Q8WVN8	A0A024R5T5 Q6ZNA4
PDB IDs		1ZUO	2KIZ 5LG0 5LG7
Enriched GO Terms of Interacting Partners?
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