AIMP1 and AIMP2

Data Source:
HPRD (in vitro)

		AIMP1	AIMP2
Description		aminoacyl tRNA synthetase complex interacting multifunctional protein 1	aminoacyl tRNA synthetase complex interacting multifunctional protein 2
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GO Annotations	Cellular Component	Extracellular Space Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Cell Surface Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex	Nucleus Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex
	Molecular Function	TRNA Binding Cytokine Activity Protein Binding Protein Homodimerization Activity GTPase Binding	Protein Binding Molecular Adaptor Activity
	Biological Process	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation TRNA Aminoacylation For Protein Translation Apoptotic Process Inflammatory Response Signal Transduction Cell-cell Signaling Leukocyte Migration Defense Response To Virus Positive Regulation Of Glucagon Secretion	TRNA Aminoacylation For Protein Translation Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Ubiquitination Type II Pneumocyte Differentiation Protein-containing Complex Assembly Positive Regulation Of Neuron Death Positive Regulation Of Aminoacyl-tRNA Ligase Activity
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation	Selenoamino acid metabolism Cytosolic tRNA aminoacylation
Drugs
Diseases		Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS			High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		50 interacting genes: AIMP2 APP ATP5F1A HOMER1 IQGAP1 MAPK14 MAPK8 MIR106B MIR107 MIR122 MIR128-1 MIR128-2 MIR138-2 MIR140 MIR15A MIR15B MIR17 MIR199A1 MIR199A2 MIR19B1 MIR19B2 MIR205 MIR206 MIR20B MIR214 MIR222 MIR25 MIR29C MIR31 MIR34A MIR34B MIR34C MIR451A MIR7-1 MIR7-2 MIR7-3 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7I OPTN RARS1 SUMO2 TSNAX	104 interacting genes: ACTB AIMP1 APP BCAS2 BEX3 BLOC1S4 BRME1 BYSL C1orf216 CBY2 CCDC153 CEP126 CHD3 DARS1 DARS2 DEAF1 DISC1 DSN1 EPRS1 EPS8 EXOC8 FGB FHL3 FUBP1 GYS1 HSPA1A ICE1 KARS1 KDR KLC2 KRT31 KRT33B KRT34 KRT36 LMO2 LMO3 LNX1 LUC7L2 MATR3 MCF2L MIR106A MIR107 MIR122 MIR128-1 MIR128-2 MIR138-2 MIR15A MIR18A MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200C MIR205 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR34A MIR34B MIR34C MIR429 MIR451A MIR7-1 MIR7-2 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7I MIS18A NDEL1 NECAB2 NTAQ1 PFDN6 PLEKHF2 PPP2R1A PRKAA2 PRKN PSME1 RABEP1 SBK3 SIAH1 SLU7 SMURF2 SPATA18 TANK TCP11 TERF2IP TEX12 TFIP11 TRAF2 TRMT2A ZC3H12A ZGPAT
Entrez ID		9255	7965
HPRD ID		04676	02915
Ensembl ID		ENSG00000164022	ENSG00000106305
Uniprot IDs		B4DNK3 Q12904	A0A024QZY1 A8MU58 Q13155
PDB IDs		1E7Z 1EUJ 1FL0 4R3Z	4DPG 4YCU 4YCW 5A1N 5A34 5A5H 5Y6L 6ILD 6IY6 6JPV 6K39
Enriched GO Terms of Interacting Partners?
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