NOTCH1 and XRCC6

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NOTCH1	XRCC6
Description		notch receptor 1	X-ray repair cross complementing 6
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GO Annotations	Cellular Component	Golgi Membrane Acrosomal Vesicle MAML1-RBP-Jkappa- ICN1 Complex Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Adherens Junction Cell Surface Integral Component Of Membrane Apical Plasma Membrane Receptor Complex	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Extracellular Region Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytosol Membrane Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex Nonhomologous End Joining Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Coactivator Activity Enzyme Inhibitor Activity Transmembrane Signaling Receptor Activity Notch Binding Calcium Ion Binding Protein Binding Enzyme Binding Chromatin DNA Binding Identical Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Cyclin Binding Telomeric DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Cell Fate Specification Epithelial To Mesenchymal Transition Liver Development Heart Looping Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Inflammatory Response To Antigenic Stimulus Outflow Tract Morphogenesis Endocardium Development Endocardium Morphogenesis Atrioventricular Node Development Coronary Vein Morphogenesis Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Coronary Sinus Valve Morphogenesis Pulmonary Valve Morphogenesis Mitral Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Chamber Formation Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Cardiac Right Atrium Morphogenesis Cardiac Left Ventricle Morphogenesis Cardiac Right Ventricle Formation Ventricular Trabecula Myocardium Morphogenesis Growth Involved In Heart Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Cell Migration Involved In Endocardial Cushion Formation Negative Regulation Of Extracellular Matrix Constituent Secretion Pericardium Morphogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Immune Response Humoral Immune Response Cell Cycle Arrest Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Spermatogenesis Determination Of Left/right Symmetry Compartment Pattern Specification Axon Guidance Foregut Morphogenesis Endoderm Development Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Auditory Receptor Cell Fate Commitment Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Myotube Differentiation Mesenchymal Cell Development Regulation Of Somitogenesis Cell Differentiation In Spinal Cord Neural Tube Development Keratinocyte Differentiation Negative Regulation Of Ossification Lung Development Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Forebrain Development Hair Follicle Morphogenesis Animal Organ Regeneration Response To Corticosteroid Response To Muramyl Dipeptide Response To Lipopolysaccharide Embryonic Hindlimb Morphogenesis Tube Formation Skeletal Muscle Cell Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Tissue Regeneration Negative Regulation Of Catalytic Activity Positive Regulation Of Viral Genome Replication Positive Regulation Of Endothelial Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Growth Rate Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Photoreceptor Cell Differentiation Positive Regulation Of Ras Protein Signal Transduction Somatic Stem Cell Division Astrocyte Differentiation Oligodendrocyte Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Glial Cell Proliferation Cilium Assembly Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Adhesion Molecule Production Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Prostate Gland Epithelium Morphogenesis Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Arterial Endothelial Cell Differentiation Venous Endothelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Development Endocardial Cell Differentiation Vasculogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Notch Signaling Involved In Heart Development Heart Trabecula Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Biomineral Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Left/right Axis Specification Cellular Response To Follicle-stimulating Hormone Stimulus Distal Tubule Development Collecting Duct Development Glomerular Mesangial Cell Development Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Population Maintenance Negative Regulation Of Cold-induced Thermogenesis Regulation Of Extracellular Matrix Assembly Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Involved In Morphogenesis Positive Regulation Of Aorta Morphogenesis Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Anoikis Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Endothelial Cell Chemotaxis	Telomere Maintenance Activation Of Innate Immune Response DNA Ligation Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Brain Development Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Neutrophil Degranulation Innate Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Smooth Muscle Cell Proliferation Cellular Hyperosmotic Salinity Response Cellular Response To Gamma Radiation Cellular Response To X-ray Establishment Of Integrated Proviral Latency Double-strand Break Repair Via Classical Nonhomologous End Joining
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Defective LFNG causes SCDO3 RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription	2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation
Drugs
Diseases		Bicuspid aortic valve Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Crohn's disease ( 28067908) Eosinophil counts ( 32888494) Inflammatory bowel disease ( 28067908) Length of menstrual cycle ( 26732621) Mean corpuscular hemoglobin ( 32888494) Red cell distribution width ( 28957414) Triglyceride levels ( 32203549) Ulcerative colitis ( 28067908)	Breast cancer ( 29059683) Meat-related diet ( 32066663) Neuroticism ( 29255261) Pulse pressure ( 28135244) Refractive error ( 32231278)
Interacting Genes		81 interacting genes: ADAM17 AKT1 APBA1 ARL6IP5 B3GALT4 BLOC1S1 CACNA1A CAMK4 CASR CBL CCN3 CEP57L1 CNTN1 COL4A6 CTNNB1 DAZAP2 DLL1 DLL4 DTX1 DTX2 EGFL7 EP300 EXT1 FAM185A FBXW7 FURIN GFI1B GOLGA2 GOPC GSK3B HMGN5 ILK ITCH JAG1 JAG2 KAT2A KAT2B KIAA1191 LCK LEF1 LFNG LINC00260 LINC02907 LNX2 MAGEA1 MAGED1 MAML1 MAML2 MAML3 MAP3K1 MDM2 MEF2C MFNG NFKB1 NUMB NUMBL PIK3CG POFUT1 POU2AF1 PRKCD PSEN1 PSEN2 RBP3 RBPJ REL RELA RHOA RUNX3 SMAD3 SNAI1 SNW1 TLE3 USP10 USP12 USP2 USP7 WDR12 WWP1 XIAP XRCC6 YY1	135 interacting genes: ABCD4 ABL1 ACD ADCY7 APEX1 AR ARAP1 ATP23 ATP6V1E1 BARD1 BAZ1A BTG1 CAPN11 CBX5 CCNA1 CCT3 CD40 CDCA5 CDK2 CDKN1A CEBPA CENPU CHAF1A CHEK1 CLTC CLU CMTM6 COIL COPB1 CREBBP CSNK2A1 CTBP2 DLX2 DNTT DUX4 DYSF EFNA1 EGFR EID1 ELF3 EP300 EPS8 ETS1 FMNL1 GAL3ST4 GSE1 GZMA GZMB HERPUD1 HMGA2 HOXB7 HOXC4 HOXD4 HSF1 HTT ILVBL JPT2 KAT2A KAT2B KIAA0408 LIG3 MAP2K5 MAP4K2 MAPK8 MRE11 MSX2 NAA15 NCF4 NCL NCOA6 NIT1 NOTCH1 PAEP PAFAH1B3 PARP1 PCNA PDK1 PDPK1 PDX1 PECAM1 PGAM1 PGR PIN1 PLGRKT PNRC2 POR POU2F1 POU2F2 PRKDC PRPF40A PTEN PTTG1 QRSL1 RASA1 RBBP4 RGS2 RNF126 RNF146 RPLP1 RPS10 RRAS2 RUNX2 SDHC SELENOF SERPINA2 SERPINB9 SET SGO1 SIRT3 SKIL SMAD3 SMAD7 SNTA1 SNU13 SPARC SUMO2 TAC1 TADA3 TBCD TCF4 TERF2 TERF2IP TERT TOP1 TP53 UBC USP14 VAV1 VBP1 WBP4 WRN XRCC5 YWHAZ ZBTB7A ZNF512B
Entrez ID		4851	2547
HPRD ID		01827	01071
Ensembl ID		ENSG00000148400	ENSG00000196419
Uniprot IDs		P46531	A0A024R1N4 B1AHC9 B4DE32 B4E356 P12956
PDB IDs		1PB5 1TOZ 1YYH 2F8X 2F8Y 2HE0 2VJ3 3ETO 3I08 3L95 3NBN 3V79 4CUD 4CUE 4CUF 4D0E 4D0F 5FM9 5FMA 5KZO 5L0R 5UB5 6IDF 6PY8	1JEQ 1JEY 1JJR 3RZX 5Y3R 6ERF 6ERG 6ERH 6ZHA 6ZHE
Enriched GO Terms of Interacting Partners?
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