IDI2 and LDB1

Data Source:
BioGRID (two hybrid)

		IDI2	LDB1
Description		isopentenyl-diphosphate delta isomerase 2	LIM domain binding 1
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GO Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol Intracellular Membrane-bounded Organelle	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cell Leading Edge Protein-containing Complex Beta-catenin-TCF Complex
	Molecular Function	Isopentenyl-diphosphate Delta-isomerase Activity Protein Binding Hydrolase Activity Metal Ion Binding	RNA Polymerase II Activating Transcription Factor Binding DNA Binding Chromatin Binding Transcription Coregulator Activity Protein Binding Enzyme Binding LIM Domain Binding Protein Homodimerization Activity Protein Self-association DNA-binding Transcription Factor Binding
	Biological Process	Cholesterol Biosynthetic Process Isoprenoid Biosynthetic Process Isopentenyl Diphosphate Biosynthetic Process Isopentenyl Diphosphate Metabolic Process Dimethylallyl Diphosphate Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Gastrulation With Mouth Forming Second Hair Follicle Development Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Multicellular Organism Development Nervous System Development Anterior/posterior Axis Specification Epithelial Structure Maintenance Wnt Signaling Pathway Cerebellar Purkinje Cell Differentiation Cellular Component Assembly Neuron Differentiation Regulation Of Cell Migration Regulation Of Transcription Elongation From RNA Polymerase II Promoter Somatic Stem Cell Population Maintenance Regulation Of Kinase Activity Histone H3-K4 Acetylation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hemoglobin Biosynthetic Process Mesendoderm Development Regulation Of Focal Adhesion Assembly Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		Cholesterol biosynthesis	RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462)	General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Pulse pressure ( 30578418)
Interacting Genes		1 interacting genes: LDB1	32 interacting genes: ATXN1 CTDSP1 DNMT3L ESR1 IDI2 IRAK3 ISL1 ISL2 LHX1 LHX2 LHX3 LHX4 LHX6 LHX8 LHX9 LMO1 LMO2 LMO3 LMO4 LMX1A LMX1B LSM7 POLR1B PSMA1 PSMD10 RLIM SP1 SSBP1 SSBP2 SSBP3 SSBP4 TOLLIP
Entrez ID		91734	8861
HPRD ID		17127	09144
Ensembl ID		ENSG00000148377	ENSG00000198728
Uniprot IDs		Q9BXS1	A0A6E1WJ75 Q86U70
PDB IDs		2PNY	2XJY 2XJZ 2YPA 6TYD
Enriched GO Terms of Interacting Partners?
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