USP6 and MYL2

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		USP6	MYL2
Description		ubiquitin specific peptidase 6	myosin light chain 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Plasma Membrane Recycling Endosome	Cytosol Cytoskeleton Actin Cytoskeleton Myosin Complex Myofibril Sarcomere A Band Cardiac Myofibril
	Molecular Function	Nucleic Acid Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity GTPase Activator Activity Protein Binding Calmodulin Binding	Actin Monomer Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding
	Biological Process	Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Transport Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Vesicle-mediated Transport Activation Of GTPase Activity	Regulation Of The Force Of Heart Contraction Regulation Of Striated Muscle Contraction Heart Development Muscle Filament Sliding Negative Regulation Of Cell Growth Cardiac Myofibril Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Positive Regulation Of The Force Of Heart Contraction
Pathways			Striated Muscle Contraction
Drugs
Diseases			Hypertrophic cardiomyopathy (HCM)
GWAS		PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575)	Alcohol consumption ( 21270382) Alcohol consumption (drinkers vs non-drinkers) ( 28485404) Alcohol consumption (max-drinks) ( 29460428) Body mass index ( 24861553) Coffee consumption ( 29367735) Coronary heart disease ( 23364394) Drinking behavior ( 23364009) Gamma glutamyl transpeptidase ( 21909109) Glycemic traits ( 23575436) Gout ( 25646370) HDL cholesterol ( 21909109) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 30718733) Metabolic syndrome ( 25705158) Metabolic syndrome (multivariate analysis) ( 29632305) Neutrophil count ( 29403010) Serum uric acid levels ( 32514006) Urate levels ( 31578528) White blood cell count ( 29403010)
Interacting Genes		18 interacting genes: ANKRD11 ANKRD44 APP ATXN7L3 CABP2 CALM2 CDC42 EXOSC8 JAK1 JUN MDFI MYL2 RAB33B RAC1 RIPPLY1 TFIP11 UBC ZNF76	12 interacting genes: CDC42BPA GJB5 LRSAM1 MYOC NHP2 PAK2 PKM PPP1R12C PSORS1C2 TRIM63 USP6 ZNF529
Entrez ID		9098	4633
HPRD ID		06827	01181
Ensembl ID		ENSG00000129204	ENSG00000111245
Uniprot IDs		P35125	P10916 Q6IB42
PDB IDs			5TBY
Enriched GO Terms of Interacting Partners?
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