SH2D2A and MAPK7

Data Source:
BioGRID (two hybrid)

		SH2D2A	MAPK7
Description		SH2 domain containing 2A	mitogen-activated protein kinase 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body
	Molecular Function	Protein Binding SH3 Domain Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Angiogenesis Signal Transduction Cell Population Proliferation Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway	MAPK Cascade Cell Cycle Signal Transduction Axon Guidance Peptidyl-serine Phosphorylation CAMP-mediated Signaling Negative Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		VEGFA-VEGFR2 Pathway	ERK/MAPK targets ERK/MAPK targets Signalling to ERK5 Signalling to ERK5 ERKs are inactivated Senescence-Associated Secretory Phenotype (SASP) Gastrin-CREB signalling pathway via PKC and MAPK RET signaling
Drugs			Acetylsalicylic acid Minocycline Fostamatinib
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) SjÃ¶gren's syndrome ( 28076899)	Alzheimer's disease ( 30636644)
Interacting Genes		34 interacting genes: APPL1 AR ARID5A CRK DAPK1 EGFR ERBB2 ERBB3 ERBB4 GAB1 ITK KDR KIT LCK LINC02875 LNX1 LRRFIP1 LRRK1 MAP3K2 MAPK7 MET MFHAS1 NAA16 PLCG1 PPP1R21 SOCS3 SPTB STAT3 SYK TSC1 TXK VCP ZHX3 ZSCAN1	30 interacting genes: ACTN4 APP CCDC6 EGLN3 ELK4 ETS1 FGF21 FOS GJA1 GOLGB1 GPSM3 MACIR MAP2K5 MEF2A MEF2C MEF2D MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RXRA SGK1 SH2D2A UBE2C YWHAB YWHAE ZBED6CL ZKSCAN1
Entrez ID		9047	5598
HPRD ID		05152	03952
Ensembl ID		ENSG00000027869	ENSG00000166484
Uniprot IDs		Q5UBZ2 Q5UBZ3 Q9NP31	A0A024QZ20 Q13164
PDB IDs			2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ 5O7I 6HKM 6HKN
Enriched GO Terms of Interacting Partners?
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