SH2D2A and MAP3K2

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SH2D2A	MAP3K2
Description		SH2 domain containing 2A	mitogen-activated protein kinase kinase kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleoplasm Cytosol
	Molecular Function	Protein Binding SH3 Domain Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Angiogenesis Signal Transduction Cell Population Proliferation Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway	Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus
Pathways		VEGFA-VEGFR2 Pathway
Drugs			Bosutinib Fostamatinib
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) SjÃ¶gren's syndrome ( 28076899)	Protein C levels ( 28082259)
Interacting Genes		34 interacting genes: APPL1 AR ARID5A CRK DAPK1 EGFR ERBB2 ERBB3 ERBB4 GAB1 ITK KDR KIT LCK LINC02875 LNX1 LRRFIP1 LRRK1 MAP3K2 MAPK7 MET MFHAS1 NAA16 PLCG1 PPP1R21 SOCS3 SPTB STAT3 SYK TSC1 TXK VCP ZHX3 ZSCAN1	24 interacting genes: BIRC2 CTNNB1 IKBKG MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAPK8 NEDD4 NEDD4L NFKBIA PIBF1 PKN2 SH2D2A SMURF1 STAMBP STUB1 USP2 WNK1 XIAP YWHAE YWHAG YWHAZ
Entrez ID		9047	10746
HPRD ID		05152	10068
Ensembl ID		ENSG00000027869	ENSG00000169967
Uniprot IDs		Q5UBZ2 Q5UBZ3 Q9NP31	A0A024RAH0 Q9Y2U5
PDB IDs			2CU1 2NPT 5EX0 5HQ8
Enriched GO Terms of Interacting Partners?
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