SH2D2A and ZHX3

Data Source:
BioGRID (two hybrid)

		SH2D2A	ZHX3
Description		SH2 domain containing 2A	zinc fingers and homeoboxes 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding SH3 Domain Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Angiogenesis Signal Transduction Cell Population Proliferation Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated
Pathways		VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) SjÃ¶gren's syndrome ( 28076899)	Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 33020668) Fasting blood glucose adjusted for BMI ( 25625282) Heel bone mineral density ( 30598549) Height ( 31562340) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 29403010) Male-pattern baldness ( 28196072) Multiple sclerosis ( 31604244 24076602) Non-response to bupropion and depression ( 27622933) Refractive error ( 32231278) Resting heart rate ( 27798624) Total cholesterol levels ( 29403010) Type 2 diabetes ( 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		34 interacting genes: APPL1 AR ARID5A CRK DAPK1 EGFR ERBB2 ERBB3 ERBB4 GAB1 ITK KDR KIT LCK LINC02875 LNX1 LRRFIP1 LRRK1 MAP3K2 MAPK7 MET MFHAS1 NAA16 PLCG1 PPP1R21 SOCS3 SPTB STAT3 SYK TSC1 TXK VCP ZHX3 ZSCAN1	6 interacting genes: ATXN1 NFYA NLK SH2D2A ZHX1 ZHX2
Entrez ID		9047	23051
HPRD ID		05152	10320
Ensembl ID		ENSG00000027869	ENSG00000174306
Uniprot IDs		Q5UBZ2 Q5UBZ3 Q9NP31	Q9H4I2
PDB IDs			2DA5 2DN0
Enriched GO Terms of Interacting Partners?
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