OTULIN and SPART

Data Source:
BioGRID (two hybrid)

		OTULIN	SPART
Description		OTU deubiquitinase with linear linkage specificity	spartin
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GO Annotations	Cellular Component	Cytoplasm Cytosol LUBAC Complex	Cytoplasm Mitochondrial Outer Membrane Lipid Droplet Cytosol Plasma Membrane Midbody Synapse
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Sprouting Angiogenesis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Ubiquitination Protein Phosphopantetheinylation Negative Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Inflammatory Response Regulation Of Canonical Wnt Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Linear Deubiquitination	Abscission Negative Regulation Of BMP Signaling Pathway Lipid Droplet Organization Negative Regulation Of Collateral Sprouting In Absence Of Injury Neuromuscular Process Cell Division Regulation Of Mitochondrial Membrane Potential Adipose Tissue Development
Pathways		Regulation of TNFR1 signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Asthma ( 31959851 31619474) Asthma (childhood onset) ( 31036433) Cerebrospinal fluid neurofilament light levels ( 31930058)
Interacting Genes		11 interacting genes: BCL10 DAZAP2 DVL2 FAM168A OTUD7B SFT2D1 SPART SPATA2 SUSD6 TMEM239 UBE2D1	22 interacting genes: APP APPL1 DESI2 EPN2 EPS15 GPR35 ITCH MAP3K1 OTUB2 OTUD7B OTULIN PLIN3 PRKAR1A RABGEF1 SMURF1 SMURF2 TUBA1A UBAC1 USP5 WWP2 YOD1 ZFYVE9
Entrez ID		90268	23111
HPRD ID		14266	06170
Ensembl ID		ENSG00000154124	ENSG00000133104
Uniprot IDs		Q96BN8	A0A024RDV9 Q8N0X7
PDB IDs		3ZNV 3ZNX 3ZNZ 4KSJ 4KSK 4KSL 4OYK 4P0B 5OE7 6I9C 6SAK	2DL1 4U7I
Enriched GO Terms of Interacting Partners?
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