SPART and YOD1

Data Source:
BioGRID (two hybrid)

		SPART	YOD1
Description		spartin	YOD1 deubiquitinase
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GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Lipid Droplet Cytosol Plasma Membrane Midbody Synapse	Cytoplasm Cytosol
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity Ubiquitinyl Hydrolase Activity Lys48-specific Deubiquitinase Activity
	Biological Process	Abscission Negative Regulation Of BMP Signaling Pathway Lipid Droplet Organization Negative Regulation Of Collateral Sprouting In Absence Of Injury Neuromuscular Process Cell Division Regulation Of Mitochondrial Membrane Potential Adipose Tissue Development	Macroautophagy Protein Deubiquitination Protein Phosphopantetheinylation Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination
Pathways			Ovarian tumor domain proteases
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS			Systolic blood pressure ( 28234671)
Interacting Genes		22 interacting genes: APP APPL1 DESI2 EPN2 EPS15 GPR35 ITCH MAP3K1 OTUB2 OTUD7B OTULIN PLIN3 PRKAR1A RABGEF1 SMURF1 SMURF2 TUBA1A UBAC1 USP5 WWP2 YOD1 ZFYVE9	30 interacting genes: BIRC3 DAZAP2 DDIT4L FAM168A INCA1 LMO2 MKRN1 NEDD4 NGRN PLEKHB2 PSMA7 RFC2 RIPK1 RNF216 SHARPIN SNCA SPART TP53BP2 TRAF6 TRIM54 TRIM55 TRIM63 TRIM8 UBC UBE3A UBXN6 USP15 USP21 VCP ZFP57
Entrez ID		23111	55432
HPRD ID		06170	10312
Ensembl ID		ENSG00000133104	ENSG00000180667
Uniprot IDs		A0A024RDV9 Q8N0X7	Q5VVQ6
PDB IDs		2DL1 4U7I	4BOQ 4BOS 4BOZ
Enriched GO Terms of Interacting Partners?
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