MAP3K14 and PEBP1

Data Source:
HPRD (in vivo)

		MAP3K14	PEBP1
Description		mitogen-activated protein kinase kinase kinase 14	phosphatidylethanolamine binding protein 1
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GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle	Nucleus Cytosol Extracellular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity	RNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Phosphatidylethanolamine Binding Enzyme Binding Protein Kinase Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Protein Phosphorylation Immune Response I-kappaB Kinase/NF-kappaB Signaling Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response To Virus Cellular Response To Mechanical Stimulus	MAPK Cascade Negative Regulation Of Endopeptidase Activity Negative Regulation Of MAPK Cascade
Pathways		CD28 dependent PI3K/Akt signaling Dectin-1 mediated noncanonical NF-kB signaling TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs			Copper
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 31959851 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Cognitive function ( 28093568) Joint damage in rheumatoid arthritis ( 26498133) Male-pattern baldness ( 28196072) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Plateletcrit ( 32888494)	Blood protein levels ( 30072576) Morphine dose requirement in tonsillectomy and adenoidectomy surgery ( 24909733)
Interacting Genes		42 interacting genes: ALPL BIRC3 BRCA1 CASP8 CDC37 CHUK EDAR EEF1A1 EGFR ELP1 FBL GRB10 GRB14 GRB7 HSP90AA1 HSP90AB1 IKBKB IKBKG MAP2K4 MAP3K7 MAP3K8 MAPK3 NFKB2 NFKBIA PEBP1 PELI3 RIPK1 RPL30 RPL4 RPL5 RPL6 RPS11 RPS13 SLC9A1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM55 TRIM63 ZFP91	23 interacting genes: BRAF CACHD1 CHUK ERBB2 GRK2 GSDMB IKBKB MAP2K1 MAP3K14 MAP3K7 MAPK1 MED10 NKX3-1 NR2C2 PICK1 PPARD PRKCA PRKCB PRKCD PRKCG PRKCZ RAF1 STC2
Entrez ID		9020	5037
HPRD ID		05230	06850
Ensembl ID		ENSG00000006062	ENSG00000089220
Uniprot IDs		Q68D39 Q99558	D9IAI1 P30086
PDB IDs		4DN5 4G3D 4IDT 4IDV 6WPP 6Z1Q 6Z1T	1BD9 1BEH 2L7W 2QYQ
Enriched GO Terms of Interacting Partners?
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