MAP3K14 and ALPL

Data Source:
HPRD (in vivo, two hybrid)

		MAP3K14	ALPL
Description		mitogen-activated protein kinase kinase kinase 14	alkaline phosphatase, biomineralization associated
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle	Extracellular Region Plasma Membrane Membrane Extracellular Matrix Anchored Component Of Membrane Extracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity	Alkaline Phosphatase Activity Protein Binding Pyrophosphatase Activity Metal Ion Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Protein Phosphorylation Immune Response I-kappaB Kinase/NF-kappaB Signaling Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response To Virus Cellular Response To Mechanical Stimulus	Skeletal System Development Osteoblast Differentiation Endochondral Ossification Developmental Process Involved In Reproduction Dephosphorylation Response To Lipopolysaccharide Response To Vitamin D Response To Antibiotic Response To Glucocorticoid Cellular Response To Organic Cyclic Compound Cementum Mineralization
Pathways		CD28 dependent PI3K/Akt signaling Dectin-1 mediated noncanonical NF-kB signaling TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Post-translational modification: synthesis of GPI-anchored proteins
Drugs			Mersalyl
Diseases			Hypophosphatasia
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 31959851 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Cognitive function ( 28093568) Joint damage in rheumatoid arthritis ( 26498133) Male-pattern baldness ( 28196072) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Plateletcrit ( 32888494)	Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) B6 vitamer levels (multivariate analysis) ( 30583557) Blood metabolite ratios ( 24816252) Calcific aortic valve stenosis ( 32141789) Folate pathway vitamin levels ( 19303062 19744961) Heel bone mineral density ( 30598549) Hematological and biochemical traits ( 20139978) Kidney stones ( 26272126 31729369) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Metabolic traits ( 21886157) Metabolite levels ( 23823483) Phosphorus levels ( 29403010 20558539) Plasma pyridoxal phosphate to pyridoxal ratio ( 31641590) Pyridoxal 5'-phosphate levels ( 25972531 31641590) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Serum alkaline phosphatase levels ( 31666285 29403010) Urinary metabolite levels in chronic kidney disease ( 31959995) Urolithiasis ( 30975718) Vitamin B levels in ischemic stroke ( 25147783)
Interacting Genes		42 interacting genes: ALPL BIRC3 BRCA1 CASP8 CDC37 CHUK EDAR EEF1A1 EGFR ELP1 FBL GRB10 GRB14 GRB7 HSP90AA1 HSP90AB1 IKBKB IKBKG MAP2K4 MAP3K7 MAP3K8 MAPK3 NFKB2 NFKBIA PEBP1 PELI3 RIPK1 RPL30 RPL4 RPL5 RPL6 RPS11 RPS13 SLC9A1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM55 TRIM63 ZFP91	6 interacting genes: ALOX5 EEF1A1 MAP3K14 SRPK2 TRAF2 TRAF3
Entrez ID		9020	249
HPRD ID		05230	01377
Ensembl ID		ENSG00000006062	ENSG00000162551
Uniprot IDs		Q68D39 Q99558	A0A024RAB4 P05186
PDB IDs		4DN5 4G3D 4IDT 4IDV 6WPP 6Z1Q 6Z1T
Enriched GO Terms of Interacting Partners?
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