PEBP1 and NR2C2

Data Source:
HPRD (in vivo)

		PEBP1	NR2C2
Description		phosphatidylethanolamine binding protein 1	nuclear receptor subfamily 2 group C member 2
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GO Annotations	Cellular Component	Nucleus Cytosol Extracellular Exosome	Chromatin Nucleoplasm
	Molecular Function	RNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Phosphatidylethanolamine Binding Enzyme Binding Protein Kinase Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MAPK Cascade Negative Regulation Of Endopeptidase Activity Negative Regulation Of MAPK Cascade	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Spermatogenesis Nervous System Development Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Embryonic Development Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development
Pathways		MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Nuclear Receptor transcription pathway
Drugs		Copper
Diseases
GWAS		Blood protein levels ( 30072576) Morphine dose requirement in tonsillectomy and adenoidectomy surgery ( 24909733)	Alcohol and nicotine co-dependence ( 22488850)
Interacting Genes		23 interacting genes: BRAF CACHD1 CHUK ERBB2 GRK2 GSDMB IKBKB MAP2K1 MAP3K14 MAP3K7 MAPK1 MED10 NKX3-1 NR2C2 PICK1 PPARD PRKCA PRKCB PRKCD PRKCG PRKCZ RAF1 STC2	23 interacting genes: AR CD2AP CDC37 CHUK ESR1 FKBP5 HDAC4 HNF4A HSP90AA1 HSP90AB1 IKBKB ITSN2 JAZF1 KDM1A NR2C1 NR2C2AP PEBP1 RAC1 RXRB TAB1 TAB2 TRAF2 TRIM55
Entrez ID		5037	7182
HPRD ID		06850	03253
Ensembl ID		ENSG00000089220	ENSG00000177463
Uniprot IDs		D9IAI1 P30086	F2YGU2 P49116
PDB IDs		1BD9 1BEH 2L7W 2QYQ	3P0U
Enriched GO Terms of Interacting Partners?
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