WASF1 and NYAP2

Data Source:
BioGRID (pull down)

		WASF1	NYAP2
Description		WASP family member 1	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Cytoskeleton Focal Adhesion Actin Cytoskeleton Lamellipodium SCAR Complex Dendrite Cytoplasm Protein-containing Complex Postsynapse
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Arp2/3 Complex Binding	Protein Binding
	Biological Process	Receptor-mediated Endocytosis Rac Protein Signal Transduction Actin Cytoskeleton Organization Actin Filament Polymerization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein-containing Complex Assembly Mitochondrion Morphogenesis Lamellipodium Morphogenesis Dendrite Extension Modification Of Postsynaptic Actin Cytoskeleton Dendritic Transport Of Mitochondrion Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Phosphatidylinositol 3-kinase Signaling Neuron Projection Morphogenesis
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS			Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Insulin levels in response to oral glucose tolerance test (fasting) ( 29093273) Menopause (age at onset) ( 23307926) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI) ( 27416945) Neurociticism ( 29500382) Smoking status (ever vs never smokers) ( 30643258) Squamous cell lung carcinoma ( 28604730) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 30910378)
Interacting Genes		40 interacting genes: ABI1 ABI3 ABL1 ACTB ACTG1 ACTR2 ACTR3 BAD BAIAP2 BRK1 CCDC196 CDC42 CDK5 CRK CXCL8 CYFIP2 DNMBP EFHC1 FYN GNAI1 GRB2 HSF2BP IFT20 IL12A ING5 LMO2 MAPKAPK2 NCK1 NCK2 NCKAP1 NYAP2 OSTF1 PFN1 PRKAR2A PSTPIP1 RAC1 SORBS2 SRGAP3 TRAF2 TRIP10	6 interacting genes: AGFG1 CYFIP1 MORN4 NCKAP1 PIK3R1 WASF1
Entrez ID		8936	57624
HPRD ID		05434	13867
Ensembl ID		ENSG00000112290	ENSG00000144460
Uniprot IDs		Q92558	Q9P242
PDB IDs		3P8C 4N78
Enriched GO Terms of Interacting Partners?
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