WASF1 and CXCL8

Data Source:
HPRD (in vitro)

		WASF1	CXCL8
Description		WASP family member 1	C-X-C motif chemokine ligand 8
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GO Annotations	Cellular Component	Mitochondrial Outer Membrane Cytoskeleton Focal Adhesion Actin Cytoskeleton Lamellipodium SCAR Complex Dendrite Cytoplasm Protein-containing Complex Postsynapse	Extracellular Region Extracellular Space
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Arp2/3 Complex Binding	Interleukin-8 Receptor Binding Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding
	Biological Process	Receptor-mediated Endocytosis Rac Protein Signal Transduction Actin Cytoskeleton Organization Actin Filament Polymerization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein-containing Complex Assembly Mitochondrion Morphogenesis Lamellipodium Morphogenesis Dendrite Extension Modification Of Postsynaptic Actin Cytoskeleton Dendritic Transport Of Mitochondrion Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Angiogenesis Response To Molecule Of Bacterial Origin Chemotaxis Inflammatory Response Cell Cycle Arrest Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Positive Regulation Of Cellular Biosynthetic Process Receptor Internalization Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction PERK-mediated Unfolded Protein Response Neutrophil Activation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Negative Regulation Of Cell Adhesion Molecule Production Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis Regulation Of Entry Of Bacterium Into Host Cell
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Senescence-Associated Secretory Phenotype (SASP) Peptide ligand-binding receptors Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress G alpha (i) signalling events Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling
Drugs			ABT-510 MDX-018 Rivanicline Tapinarof
Diseases
GWAS			Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566)
Interacting Genes		40 interacting genes: ABI1 ABI3 ABL1 ACTB ACTG1 ACTR2 ACTR3 BAD BAIAP2 BRK1 CCDC196 CDC42 CDK5 CRK CXCL8 CYFIP2 DNMBP EFHC1 FYN GNAI1 GRB2 HSF2BP IFT20 IL12A ING5 LMO2 MAPKAPK2 NCK1 NCK2 NCKAP1 NYAP2 OSTF1 PFN1 PRKAR2A PSTPIP1 RAC1 SORBS2 SRGAP3 TRAF2 TRIP10	20 interacting genes: ACKR1 ARFGAP3 BAG6 CCL2 CCL4 CCL5 CCL8 CTSL CXCR1 CXCR2 EP300 ERBB2 GNAI2 IL12A MMP9 PF4 POMGNT1 SDC1 SGTA WASF1
Entrez ID		8936	3576
HPRD ID		05434	00909
Ensembl ID		ENSG00000112290	ENSG00000169429
Uniprot IDs		Q92558	A0A024RDA5 P10145
PDB IDs		3P8C 4N78	1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8 4XDX 5D14 5WDZ 6LFM 6LFO 6N2U
Enriched GO Terms of Interacting Partners?
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