TAX1BP1 and KIF5B

Data Source:
BioGRID (two hybrid)

		TAX1BP1	KIF5B
Description		Tax1 binding protein 1	kinesin family member 5B
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Cytosol Kinesin Complex Microtubule Membrane Vesicle Dendrite Cytoplasm Centriolar Satellite Ciliary Rootlet Axonal Growth Cone Phagocytic Vesicle Perinuclear Region Of Cytoplasm Axon Cytoplasm
	Molecular Function	Protein Binding Kinase Binding Metal Ion Binding	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding JUN Kinase Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity Identical Protein Binding Cadherin Binding Microtubule Lateral Binding
	Biological Process	Apoptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Negative Regulation Of Apoptotic Process	Microtubule-based Movement Cytoplasm Organization Axon Guidance Hippocampus Development Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Vesicle Fusion Positive Regulation Of Synaptic Transmission, GABAergic Stress Granule Disassembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Membrane Potential Positive Regulation Of Potassium Ion Transport Vesicle Transport Along Microtubule Synaptic Vesicle Transport Centrosome Localization Cellular Response To Interferon-gamma Plus-end-directed Vesicle Transport Along Microtubule Positive Regulation Of Intracellular Protein Transport Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Voltage-gated Sodium Channel Activity Anterograde Neuronal Dense Core Vesicle Transport Retrograde Neuronal Dense Core Vesicle Transport
Pathways		Regulation of TNFR1 signaling Negative regulators of DDX58/IFIH1 signaling	MHC class II antigen presentation Insulin processing RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Alcoholic chronic pancreatitis ( 28754779) Allergic rhinitis ( 30013184) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Hypospadias ( 25108383) Metabolite levels ( 23823483)	Anti-saccade response ( 29064472) Bipolar disorder with mood-incongruent psychosis ( 23092984) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glycine levels ( 30837465) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		75 interacting genes: ARHGAP1 AZI2 C18orf25 CBX8 COG7 CWF19L2 CXXC1 DAXX DAZAP2 DSTN EMILIN1 FAM161A FAM168A FAM189A2 FAM90A1 FOXC2 GABARAP GABARAPL1 GABARAPL2 IGFN1 IKBKG KANK2 KAT5 KIF5B L3MBTL2 LGALS8 LITAF LMO3 LNX1 LRATD2 MAP1LC3B MAP1LC3C MRPL11 MRPL53 NMRK1 NTAQ1 ORC5 PIBF1 PLEKHB2 PLEKHN1 POLR1C RAB18 RAD18 RAD23B RAD54L2 RB1CC1 RIPK1 RNF11 SCNM1 SH3GLB1 SSX2 STARD13 TBC1D15 TBC1D17 TCAF1 TCEA2 TCL1A TNFAIP3 TNIP1 TNIP3 TRAF4 TRAF6 TRAPPC6A TRIM14 TRIM45 TSEN2 TSG101 TSHZ3 UBA52 UBASH3A UBB UBC UBTFL1 USP2 ZNF446	36 interacting genes: APC BAG4 CCDC136 CDC5L CDR2 DTNB FHL2 GCC1 GSK3B HSF2BP KIF5A KLC3 KTN1 LBX1 MEOX2 MYO5A NCOA2 NDRG1 POLR2G POU6F2 PRKAR1B PRKAR2B RAPGEF2 RRBP1 SNAP23 SNAP25 SUMO2 SYBU TAX1BP1 VPS52 YWHAB YWHAG YWHAH YWHAQ YWHAZ ZBTB8A
Entrez ID		8887	3799
HPRD ID		05618	07214
Ensembl ID		ENSG00000106052	ENSG00000170759
Uniprot IDs		B4DSG5 Q86VP1	P33176 Q6P164 V9HW29
PDB IDs		2M7Q 4BMJ 4NLH 4Z4K 4Z4M 5AAS 5YT6 5Z7G	1BG2 1MKJ 2P4N 3J8X 3J8Y 4HNA 4LNU 5LT0 5LT1 5LT2 5LT3 5LT4 6OJQ
Enriched GO Terms of Interacting Partners?
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