PER2 and TPT1

Data Source:
BioGRID (two hybrid)

		PER2	TPT1
Description		period circadian regulator 2	tumor protein, translationally-controlled 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Spindle Pole Extracellular Space Nucleus Cytoplasm Multivesicular Body Cytosol Cytoplasmic Microtubule Extracellular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Transcription Coactivator Activity Protein Binding	RNA Binding Calcium Ion Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Ischemia Glycogen Biosynthetic Process Gluconeogenesis Fatty Acid Metabolic Process Circadian Rhythm Regulation Of Vasoconstriction Lactate Biosynthetic Process Negative Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis Regulation Of Insulin Secretion White Fat Cell Differentiation Regulation Of Cell Cycle Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Negative Regulation Of Fat Cell Proliferation Histone H3 Deacetylation Circadian Regulation Of Translation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Transcription Regulatory Region DNA Binding	Calcium Ion Transport Cellular Calcium Ion Homeostasis Response To Virus Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		Circadian Clock
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		Familial advanced sleep phase syndrome
GWAS		Chronotype ( 26955885 30696823 27494321) Morning vs. evening chronotype ( 26955885 26835600 27494321)	Type 2 diabetes ( 25760438)
Interacting Genes		25 interacting genes: BHLHE41 BTRC CLOCK CRY1 CRY2 CSNK1D CSNK1E CSNK2B DELEC1 ELOA LENG8 LMO4 MDM2 MLH1 PER1 PER3 RORC TIMELESS TP53 TPT1 TPTEP2-CSNK1E UBE2D1 UBE2D2 UBE2D3 UBL4A	30 interacting genes: APP ATP1A1 ATP1A2 BCL2L1 CALM1 DBN1 EEF1A1 EEF1A2 EEF1B2 EEF1D FANCA HSPB1 IKBKG LIG4 MCL1 MCPH1 MDM2 MLC1 NKX3-1 NOTCH3 PER2 PLK1 RBBP6 RPLP1 SNX6 SPP1 STEAP3 TRIP13 TUBB2A VHL
Entrez ID		8864	7178
HPRD ID		04575	15979
Ensembl ID		ENSG00000132326	ENSG00000133112
Uniprot IDs		O15055	A0A024RDY2 A0A0B4J2C3 A0A0P1J1R0 P13693
PDB IDs		6OF7	1YZ1 2HR9 3EBM 4Z9V 5O9L 5O9M 6IZB 6IZE
Enriched GO Terms of Interacting Partners?
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