TPT1 and ATP1A2

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		TPT1	ATP1A2
Description		tumor protein, translationally-controlled 1	ATPase Na+/K+ transporting subunit alpha 2
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Extracellular Space Nucleus Cytoplasm Multivesicular Body Cytosol Cytoplasmic Microtubule Extracellular Exosome	Cytoplasm Endosome Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Membrane T-tubule Organelle Membrane Cell Projection Neuronal Cell Body Dendritic Spine Extracellular Vesicle
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding	P-type Sodium:potassium-exchanging ATPase Activity Steroid Binding Protein Binding ATP Binding Phosphatase Activity ATPase Activity ATPase-coupled Cation Transmembrane Transporter Activity Potassium Ion Binding Sodium Ion Binding Protein Heterodimerization Activity Chaperone Binding Steroid Hormone Binding
	Biological Process	Calcium Ion Transport Cellular Calcium Ion Homeostasis Response To Virus Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Neurotransmitter Uptake Behavioral Fear Response Regulation Of The Force Of Heart Contraction Regulation Of Respiratory Gaseous Exchange By Nervous System Process Potassium Ion Transport Sodium Ion Transport Cellular Sodium Ion Homeostasis Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Blood Pressure Adult Locomotory Behavior Visual Learning Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Auditory Stimulus Dephosphorylation Regulation Of Vasoconstriction Amygdala Development Olfactory Cortex Development Cellular Potassium Ion Homeostasis Ion Transmembrane Transport Response To Nicotine Locomotory Exploration Behavior Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Locomotion Negative Regulation Of Heart Contraction Positive Regulation Of Heart Contraction Negative Regulation Of Striated Muscle Contraction ATP Metabolic Process Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Regulation Of Synaptic Transmission, Glutamatergic Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Cellular Response To Mechanical Stimulus Cellular Response To Steroid Hormone Stimulus Potassium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Contraction Membrane Repolarization Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cation Transmembrane Transport Transport Across Blood-brain Barrier Proton Transmembrane Transport Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Calcium:sodium Antiporter Activity Response To Glycoside Regulation Of Cardiac Conduction Potassium Ion Import Across Plasma Membrane
Pathways			Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	Ouabain
Diseases			Alternating hemiplegia of childhood Familial or sporadic hemiplegic migraine
GWAS		Type 2 diabetes ( 25760438)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Response to antipsychotic treatment ( 23241943)
Interacting Genes		30 interacting genes: APP ATP1A1 ATP1A2 BCL2L1 CALM1 DBN1 EEF1A1 EEF1A2 EEF1B2 EEF1D FANCA HSPB1 IKBKG LIG4 MCL1 MCPH1 MDM2 MLC1 NKX3-1 NOTCH3 PER2 PLK1 RBBP6 RPLP1 SNX6 SPP1 STEAP3 TRIP13 TUBB2A VHL	1 interacting genes: TPT1
Entrez ID		7178	477
HPRD ID		15979	01665
Ensembl ID		ENSG00000133112	ENSG00000018625
Uniprot IDs		A0A024RDY2 A0A0B4J2C3 A0A0P1J1R0 P13693	A0A0S2Z3W6 P50993
PDB IDs		1YZ1 2HR9 3EBM 4Z9V 5O9L 5O9M 6IZB 6IZE
Enriched GO Terms of Interacting Partners?
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