DPM2 and DPM1

Data Source:
HPRD (in vivo)

		DPM2	DPM1
Description		dolichyl-phosphate mannosyltransferase subunit 2, regulatory	dolichyl-phosphate mannosyltransferase subunit 1, catalytic
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dolichol-phosphate-mannose Synthase Complex	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Protein Binding Enzyme Activator Activity Enzyme Regulator Activity	Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding
	Biological Process	GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane Protein N-linked Glycosylation Via Asparagine Dolichol Metabolic Process Regulation Of Protein Stability Protein O-linked Mannosylation Regulation Of Catalytic Activity	GPI Anchor Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Dolichol Metabolic Process Protein Mannosylation Protein O-linked Mannosylation
Pathways		Synthesis of dolichyl-phosphate mannose Synthesis of glycosylphosphatidylinositol (GPI) Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)	Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Body mass index ( 26426971) Glaucoma (primary angle closure) ( 27064256)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)
Interacting Genes		7 interacting genes: DPM1 DPM3 HLA-DMB PIGA PIGC SLC22A2 VKORC1	7 interacting genes: DPM2 DPM3 MEOX2 MTNR1A PTEN TDO2 ZBTB16
Entrez ID		8818	8813
HPRD ID		16028	04613
Ensembl ID		ENSG00000136908	ENSG00000000419
Uniprot IDs		O94777	A0A0S2Z4Y5 O60762 Q5QPK2
PDB IDs
Enriched GO Terms of Interacting Partners?
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