DPM1 and DPM2

Data Source:
HPRD (in vivo)

		DPM1	DPM2
Description		dolichyl-phosphate mannosyltransferase subunit 1, catalytic	dolichyl-phosphate mannosyltransferase subunit 2, regulatory
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding	Protein Binding Enzyme Activator Activity Enzyme Regulator Activity
	Biological Process	GPI Anchor Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Dolichol Metabolic Process Protein Mannosylation Protein O-linked Mannosylation	GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane Protein N-linked Glycosylation Via Asparagine Dolichol Metabolic Process Regulation Of Protein Stability Protein O-linked Mannosylation Regulation Of Catalytic Activity
Pathways		Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)	Synthesis of dolichyl-phosphate mannose Synthesis of glycosylphosphatidylinositol (GPI) Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)	Body mass index ( 26426971) Glaucoma (primary angle closure) ( 27064256)
Interacting Genes		7 interacting genes: DPM2 DPM3 MEOX2 MTNR1A PTEN TDO2 ZBTB16	7 interacting genes: DPM1 DPM3 HLA-DMB PIGA PIGC SLC22A2 VKORC1
Entrez ID		8813	8818
HPRD ID		04613	16028
Ensembl ID		ENSG00000000419	ENSG00000136908
Uniprot IDs		A0A0S2Z4Y5 O60762 Q5QPK2	O94777
PDB IDs
Enriched GO Terms of Interacting Partners?
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